دورية أكاديمية
Antinociceptive and anti-inflammatory effects of the citrus flavanone naringenin
| العنوان: | Antinociceptive and anti-inflammatory effects of the citrus flavanone naringenin |
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| المؤلفون: | Ting-Wen Chung, Shiming Li, Chi-Chien Lin, Sen-Wei Tsai |
| المصدر: | Tzu-Chi Medical Journal, Vol 31, Iss 2, Pp 81-85 (2019) |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | Anti-inflammatory, Antinociceptive, Inflammation, Naringenin, Pain, Medicine |
| الوصف: | Objective: Naringenin, a flavonoid found in citrus fruits, has notably diverse pharmacological properties. In the present study, we investigated the antinociceptive and anti-inflammatory effects of naringenin. Materials and Methods: The antinociceptive effects were evaluated using hot-plate, acetic acid-induced writhing, and tail-flick assays in mice and rats. The anti-inflammatory effects were examined by a carrageenan-induced paw edema test in rats. Results: Naringenin (100 or 200 mg/kg, oral administration) significantly delayed the reaction time of mice to thermal stimulation generated by a hot plate and a tail-flick unit and reduced the acetic acid-induced writhing response in mice. In addition, naringenin significantly decreased paw edema induced by carrageenan in rats, showing its anti-inflammatory effect. Conclusion: Our results show that naringenin has therapeutic potential with antinociceptive and anti-inflammatory properties and can further be exploited for the development of drugs for pain and inflammatory-related diseases. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1016-3190 2223-8956 |
| Relation: | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2019;volume=31;issue=2;spage=81;epage=85;aulast=Chung; https://doaj.org/toc/1016-3190; https://doaj.org/toc/2223-8956 |
| DOI: | 10.4103/tcmj.tcmj_103_18 |
| URL الوصول: | https://doaj.org/article/1ef8d82ebcec4517b0d0f8f427d04499 |
| رقم الأكسشن: | edsdoj.1ef8d82ebcec4517b0d0f8f427d04499 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 10163190 22238956 |
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| DOI: | 10.4103/tcmj.tcmj_103_18 |