دورية أكاديمية
The Quality Control of Midecamycin and the Predictive Demarcation between Its Impurities and Components
| العنوان: | The Quality Control of Midecamycin and the Predictive Demarcation between Its Impurities and Components |
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| المؤلفون: | Mingyan Yu, Weijian Wang, Wenkun Liu, Huiru Yang, Tong Sun, Haiyun Zhao, Dejun Chen |
| المصدر: | Separations, Vol 9, Iss 8, p 225 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Physics LCC:Chemistry |
| مصطلحات موضوعية: | macrolide, midecamycin, high-resolution mass spectrometry (HRMS), molecular docking, Physics, QC1-999, Chemistry, QD1-999 |
| الوصف: | Midecamycin is a 16-membered macrolide antibiotic. It can inhibit the synthesis of bacterial proteins by blocking up the activity of peptidyl transferase in the 50S ribosome. We used high-resolution mass spectrometry to analyze midecamycin, and quantitatively analyzed of each component of midecamycin produced by 18 different companies. The developed methods were validated by assessing linearity, limit of quantitation (LOQ), accuracy, precision, and robustness. Good separations were achieved for all components. Ten components of midecamycin were identified, and the contents of these components were determined in midecamycin produced by different companies. The demarcation between impurities and components of midecamycin was not clear. A ligand-docking model was used for predicting the impurities and components of midecamycin. Components and impurities were docked with the target. The results reported in this article may be important for quality control and the predictive demarcation between impurities and components of midecamycin. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2297-8739 |
| Relation: | https://www.mdpi.com/2297-8739/9/8/225; https://doaj.org/toc/2297-8739 |
| DOI: | 10.3390/separations9080225 |
| URL الوصول: | https://doaj.org/article/1f0d52d9470c4dd5becbbe9b67bc21cd |
| رقم الأكسشن: | edsdoj.1f0d52d9470c4dd5becbbe9b67bc21cd |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22978739 |
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| DOI: | 10.3390/separations9080225 |