دورية أكاديمية
أعرض في EDS

BK channels reveal novel phosphate sensitivity in SNr neurons.

التفاصيل البيبلوغرافية
العنوان: BK channels reveal novel phosphate sensitivity in SNr neurons.
المؤلفون: Juan Juan Ji, Lianwan Chen, Xuezhi Duan, Xueqin Song, Wenting Su, Peng Zhang, Li Li, Shuyun Bai, Yingchun Sun, Nobuya Inagaki
المصدر: PLoS ONE, Vol 7, Iss 12, p e52148 (2012)
بيانات النشر: Public Library of Science (PLoS), 2012.
سنة النشر: 2012
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Whether large conductance Ca(2+)-activated potassium (BK) channels are present in the substantia nigra pars reticulata (SNr) is a matter of debate. Using the patch-clamp technique, we examined the functional expression of BK channels in neurons of the SNr and showed that the channels were activated or inhibited by internal high-energy phosphates (IHEPs) at positive and negative membrane potentials, respectively. SNr neurons showed membrane potential hyperpolarization under glucose-deprivation conditions which was attenuated by paxilline, a specific BK channel blocker. In addition, Fluo-3 fluorescence recording detected an increase in the level of internal free calcium ([Ca(2+)](i)) during ischemic hyperpolarization. These results confirm that BK channels are present in SNr neurons and indicate that their unique IHEP sensitivity is requisite in neuronal ischemic responses. Bearing in mind that the K(ATP) channel blocker tolbutamide also attenuated the hyperpolarization, we suggest that BK channels may play a protective role in the basal ganglia by modulating the excitability of SNr neurons along with K(ATP) channels under ischemic stresses.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC3527394?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0052148
URL الوصول: https://doaj.org/article/1f200df8f9884caf88f6a40f05dbef9e
رقم الأكسشن: edsdoj.1f200df8f9884caf88f6a40f05dbef9e
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0052148