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Active surveillance of hepatitis E: a 10-year epidemiological analysis in a city in eastern China

التفاصيل البيبلوغرافية
العنوان: Active surveillance of hepatitis E: a 10-year epidemiological analysis in a city in eastern China
المؤلفون: Xingcheng Huang, Xiaoxiang Zheng, Lin Chen, Chunlan Zhuang, Changlin Yang, Xia Zang, Yijun Wang, Hanmin Jiang, Xiaomeng Huang, Qiang Yan, Zimin Tang, Yingying Su, Zizheng Zheng, Ting Wu, Xuefeng Zhang, Yue Huang, Shoujie Huang, Fengcai Zhu, Jun Zhang, Ningshao Xia
المصدر: Emerging Microbes and Infections, Vol 13, Iss 1 (2024)
بيانات النشر: Taylor & Francis Group, 2024.
سنة النشر: 2024
المجموعة: LCC:Infectious and parasitic diseases
LCC:Microbiology
مصطلحات موضوعية: Hepatitis E, epidemiology, surveillance, disease notification, hepatitis B, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502
الوصف: Hepatitis E virus (HEV) is an important cause of acute hepatitis, however, is highly neglected and largely underreported. This study aimed to describe the detailed epidemiology of hepatitis E (HE) through a 10-year surveillance. A community-based active hepatitis surveillance was conducted between November 2007 and October 2017 in 11 townships of Dongtai City in China, involving 355,673 residents. Serum samples were obtained from patients presenting with hepatitis symptoms for more than 3 days. Serum alanine aminotransferase (ALT) levels greater than 2.5 times the upper limit of normal (ULN) were considered acute hepatitis. Samples were subsequently tested for IgG and IgM anti-HEV antibodies, HEV RNA, and hepatitis B surface antigen (HBsAg). The data indicated the incidence of HE fluctuated downward from 2007 to 2017, with an average annual age-standardized incidence of 17.50 per 100,000, exceeding the 10.26 per 100,000 in the National Notifiable Disease Report System (NNDRS). The incidence was notably higher among males (20.95 per 100,000) and individuals aged 50–69 years (37.47 per 100,000). Genotype 4 (HEV-4) was the predominantly circulating genotype during the study period. Furthermore, the study revealed the incidence of hepatitis with HEV and hepatitis B virus (HBV) co-infection was 4.99 per 100,000. The active surveillance system identified a higher incidence of HE compared to NNDRS, with a decreased prevalence over a 10-year period. While efforts are still needed to prevent HE in high-risk populations, including individuals with hepatitis B and the elderly.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 22221751
2222-1751
Relation: https://doaj.org/toc/2222-1751
DOI: 10.1080/22221751.2024.2373315
URL الوصول: https://doaj.org/article/d1f316324be145d988080ccc01f7e1ea
رقم الأكسشن: edsdoj.1f316324be145d988080ccc01f7e1ea
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:22221751
DOI:10.1080/22221751.2024.2373315