دورية أكاديمية
Cyclic-AMP mediated drugs: differential or global reduction of eicosanoid synthesis in the isolated rat lung?
| العنوان: | Cyclic-AMP mediated drugs: differential or global reduction of eicosanoid synthesis in the isolated rat lung? |
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| المؤلفون: | Mark J. Post, Jan Dirk te Biesebeek, Johan Wemer, Hans H. van Rooij, Freek J. Zijlstra, Arijan J. Porsius |
| المصدر: | Mediators of Inflammation, Vol 1, Iss 4, Pp 255-261 (1992) |
| بيانات النشر: | Wiley, 1992. |
| سنة النشر: | 1992 |
| المجموعة: | LCC:Pathology |
| مصطلحات موضوعية: | Pathology, RB1-214 |
| الوصف: | In this study the question was addressed whether cAMP mediated drugs induce a differential reduction of branches of the arachidonic acid metabolism rather than a global reduction of eicosanoid synthesis. The isolated lungs of actively sensitized rats were employed to study prostaglandin and leukotriene release in the presence and absence of the cAMP mediated drugs theophylline, milrinone, sulmazole, isobutyl-methylxanthine and salbutamol. The release of eicosanoids as measured by RIA was predominantly basal and continuous, with a mild antigen induced stimulation only for TXB2 and the leukotrienes. All drugs reduced eicosanoid release globally. It is concluded that cAMP mediated drugs interfere with arachidonic acid metabolism at a site proximal to the branching into lipoxygenase and cyclo-oxygenase pathways. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0962-9351 1466-1861 09629351 |
| Relation: | https://doaj.org/toc/0962-9351; https://doaj.org/toc/1466-1861 |
| DOI: | 10.1155/S0962935192000395 |
| URL الوصول: | https://doaj.org/article/1f377c7cf6c545f08e75d8197e8dd1f6 |
| رقم الأكسشن: | edsdoj.1f377c7cf6c545f08e75d8197e8dd1f6 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 09629351 14661861 |
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| DOI: | 10.1155/S0962935192000395 |