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أعرض في EDS

Incidence determinants and serological correlates of reactive symptoms following SARS-CoV-2 vaccination

التفاصيل البيبلوغرافية
العنوان: Incidence determinants and serological correlates of reactive symptoms following SARS-CoV-2 vaccination
المؤلفون: Hayley Holt, David A. Jolliffe, Mohammad Talaei, Sian Faustini, Giulia Vivaldi, Matthew Greenig, Alex G. Richter, Ronan A. Lyons, Christopher J. Griffiths, Frank Kee, Aziz Sheikh, Gwyneth A. Davies, Seif O. Shaheen, Adrian R. Martineau
المصدر: npj Vaccines, Vol 8, Iss 1, Pp 1-10 (2023)
بيانات النشر: Nature Portfolio, 2023.
سنة النشر: 2023
المجموعة: LCC:Immunologic diseases. Allergy
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
مصطلحات موضوعية: Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
الوصف: Abstract Prospective population-based studies investigating associations between reactive symptoms following SARS-CoV-2 vaccination and serologic responses to vaccination are lacking. We therefore conducted a study in 9003 adults from the UK general population receiving SARS-CoV-2 vaccines as part of the national vaccination programme. Titres of combined IgG/IgA/IgM responses to SARS-CoV-2 spike (S) glycoprotein were determined in eluates of dried blood spots collected from all participants before and after vaccination. 4262 (47.3%) participants experienced systemic reactive symptoms after a first vaccine dose. Factors associating with lower risk of such symptoms included older age (aOR per additional 10 years of age 0.85, 95% CI: 0.81–0.90), male vs. female sex (0.59, 0.53–0.65) and receipt of an mRNA vaccine vs. ChAdOx1 nCoV-19 (0.29, 0.26–0.32 for BNT162b2; 0.06, 0.01–0.26 for mRNA-1273). Higher risk of such symptoms was associated with SARS-CoV-2 seropositivity and COVID-19 symptoms prior to vaccination (2.23, 1.78–2.81), but not with SARS-CoV-2 seropositivity in the absence of COVID-19 symptoms (0.94, 0.81–1.09). Presence vs. absence of self-reported anxiety or depression at enrolment associated with higher risk of such symptoms (1.24, 1.12–1.39). Post-vaccination anti-S titres were higher among participants who experienced reactive symptoms after vaccination vs. those who did not (P
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2059-0105
Relation: https://doaj.org/toc/2059-0105
DOI: 10.1038/s41541-023-00614-0
URL الوصول: https://doaj.org/article/1f48cbac4e4f43ae89f1afb89b1bf498
رقم الأكسشن: edsdoj.1f48cbac4e4f43ae89f1afb89b1bf498
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20590105
DOI:10.1038/s41541-023-00614-0