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Upregulation of FLG, LOR, and IVL Expression by Rhodiola crenulata Root Extract via Aryl Hydrocarbon Receptor: Differential Involvement of OVOL1

التفاصيل البيبلوغرافية
العنوان: Upregulation of FLG, LOR, and IVL Expression by Rhodiola crenulata Root Extract via Aryl Hydrocarbon Receptor: Differential Involvement of OVOL1
المؤلفون: Akiko Hashimoto-Hachiya, Gaku Tsuji, Mika Murai, Xianghong Yan, Masutaka Furue
المصدر: International Journal of Molecular Sciences, Vol 19, Iss 6, p 1654 (2018)
بيانات النشر: MDPI AG, 2018.
سنة النشر: 2018
المجموعة: LCC:Biology (General)
LCC:Chemistry
مصطلحات موضوعية: Rhodiola crenulata root extract, aryl hydrocarbon receptor, filaggrin, loricrin, involucrin, OVOL1, Biology (General), QH301-705.5, Chemistry, QD1-999
الوصف: Rhodiola species are antioxidative, salubrious plants that are known to inhibit oxidative stress induced by ultraviolet and γ-radiation in epidermal keratinocytes. As certain phytochemicals activate aryl hydrocarbon receptors (AHR) or OVO-like 1 (OVOL1) to upregulate the expression of epidermal barrier proteins such as filaggrin (FLG), loricrin (LOR), and involucrin (IVL), we investigated such regulation by Rhodiola crenulata root extract (RCE). We demonstrated that RCE induced FLG and LOR upregulation in an AHR-OVOL1-dependent fashion. However, RCE-mediated IVL upregulation was AHR-dependent but OVOL1-independent. Coordinated upregulation of skin barrier proteins by RCE via AHR may be beneficial in the management of barrier-disrupted inflammatory skin diseases such as atopic dermatitis.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1422-0067
Relation: http://www.mdpi.com/1422-0067/19/6/1654; https://doaj.org/toc/1422-0067
DOI: 10.3390/ijms19061654
URL الوصول: https://doaj.org/article/d1f86c2dfb0e4e978adf889fa9f57fa5
رقم الأكسشن: edsdoj.1f86c2dfb0e4e978adf889fa9f57fa5
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14220067
DOI:10.3390/ijms19061654