دورية أكاديمية
Upregulation of FLG, LOR, and IVL Expression by Rhodiola crenulata Root Extract via Aryl Hydrocarbon Receptor: Differential Involvement of OVOL1
العنوان: | Upregulation of FLG, LOR, and IVL Expression by Rhodiola crenulata Root Extract via Aryl Hydrocarbon Receptor: Differential Involvement of OVOL1 |
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المؤلفون: | Akiko Hashimoto-Hachiya, Gaku Tsuji, Mika Murai, Xianghong Yan, Masutaka Furue |
المصدر: | International Journal of Molecular Sciences, Vol 19, Iss 6, p 1654 (2018) |
بيانات النشر: | MDPI AG, 2018. |
سنة النشر: | 2018 |
المجموعة: | LCC:Biology (General) LCC:Chemistry |
مصطلحات موضوعية: | Rhodiola crenulata root extract, aryl hydrocarbon receptor, filaggrin, loricrin, involucrin, OVOL1, Biology (General), QH301-705.5, Chemistry, QD1-999 |
الوصف: | Rhodiola species are antioxidative, salubrious plants that are known to inhibit oxidative stress induced by ultraviolet and γ-radiation in epidermal keratinocytes. As certain phytochemicals activate aryl hydrocarbon receptors (AHR) or OVO-like 1 (OVOL1) to upregulate the expression of epidermal barrier proteins such as filaggrin (FLG), loricrin (LOR), and involucrin (IVL), we investigated such regulation by Rhodiola crenulata root extract (RCE). We demonstrated that RCE induced FLG and LOR upregulation in an AHR-OVOL1-dependent fashion. However, RCE-mediated IVL upregulation was AHR-dependent but OVOL1-independent. Coordinated upregulation of skin barrier proteins by RCE via AHR may be beneficial in the management of barrier-disrupted inflammatory skin diseases such as atopic dermatitis. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1422-0067 |
Relation: | http://www.mdpi.com/1422-0067/19/6/1654; https://doaj.org/toc/1422-0067 |
DOI: | 10.3390/ijms19061654 |
URL الوصول: | https://doaj.org/article/d1f86c2dfb0e4e978adf889fa9f57fa5 |
رقم الأكسشن: | edsdoj.1f86c2dfb0e4e978adf889fa9f57fa5 |
قاعدة البيانات: | Directory of Open Access Journals |
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