دورية أكاديمية
Ultrasound-assisted Peptide Nucleic Acids synthesis (US-PNAS)
| العنوان: | Ultrasound-assisted Peptide Nucleic Acids synthesis (US-PNAS) |
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| المؤلفون: | Alessandra Del Bene, Antonia D'Aniello, Stefano Tomassi, Francesco Merlino, Vincenzo Mazzarella, Rosita Russo, Angela Chambery, Sandro Cosconati, Salvatore Di Maro, Anna Messere |
| المصدر: | Ultrasonics Sonochemistry, Vol 95, Iss , Pp 106360- (2023) |
| بيانات النشر: | Elsevier, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Chemistry LCC:Acoustics. Sound |
| مصطلحات موضوعية: | Peptide Nucleic Acid, Ultrasonication, Sonochemistry, Solid-Phase Synthesis, Coupling Conditions, Chemistry, QD1-999, Acoustics. Sound, QC221-246 |
| الوصف: | Herein, we developed an innovative and easily accessible solid-phase synthetic protocol for Peptide Nucleic Acid (PNA) oligomers by systematically investigating the ultrasonication effects in all steps of the PNA synthesis (US-PNAS). When compared with standard protocols, the application of the so-obtained US-PNAS approach succeeded in improving the crude product purities and the isolated yields of different PNA, including small or medium-sized oligomers (5-mer and 9-mer), complex purine-rich sequences (like a 5-mer Guanine homoligomer and the telomeric sequence TEL-13) and longer oligomers (such as the 18-mer anti-IVS2-654 PNA and the 23-mer anti-mRNA 155 PNA). Noteworthy, our ultrasound-assisted strategy is compatible with the commercially available PNA monomers and well-established coupling reagents and only requires the use of an ultrasonic bath, which is a simple equipment generally available in most synthetic laboratories. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1350-4177 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S135041772300072X; https://doaj.org/toc/1350-4177 |
| DOI: | 10.1016/j.ultsonch.2023.106360 |
| URL الوصول: | https://doaj.org/article/1fa1eb4d80514de18f3776f1e6ad4b40 |
| رقم الأكسشن: | edsdoj.1fa1eb4d80514de18f3776f1e6ad4b40 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 13504177 |
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| DOI: | 10.1016/j.ultsonch.2023.106360 |