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Repression of cardiac hypertrophy by KLF15: underlying mechanisms and therapeutic implications.

التفاصيل البيبلوغرافية
العنوان: Repression of cardiac hypertrophy by KLF15: underlying mechanisms and therapeutic implications.
المؤلفون: Joost J Leenders, Wino J Wijnen, Ingeborg van der Made, Monika Hiller, Melissa Swinnen, Thierry Vandendriessche, Marinee Chuah, Yigal M Pinto, Esther E Creemers
المصدر: PLoS ONE, Vol 7, Iss 5, p e36754 (2012)
بيانات النشر: Public Library of Science (PLoS), 2012.
سنة النشر: 2012
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: The Kruppel-like factor (KLF) family of transcription factors regulates diverse cell biological processes including proliferation, differentiation, survival and growth. Previous studies have shown that KLF15 inhibits cardiac hypertrophy by repressing the activity of pivotal cardiac transcription factors such as GATA4, MEF2 and myocardin. We set out this study to characterize the interaction of KLF15 with putative other transcription factors. We first show that KLF15 interacts with myocardin-related transcription factors (MRTFs) and strongly represses the transcriptional activity of MRTF-A and MRTF-B. Second, we identified a region within the C-terminal zinc fingers of KLF15 that contains the nuclear localization signal. Third, we investigated whether overexpression of KLF15 in the heart would have therapeutic potential. Using recombinant adeno-associated viruses (rAAV) we have overexpressed KLF15 specifically in the mouse heart and provide the first evidence that elevation of cardiac KLF15 levels prevents the development of cardiac hypertrophy in a model of Angiotensin II induced hypertrophy.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC3346753?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0036754
URL الوصول: https://doaj.org/article/1fd6139a87124b14b3bf8ee5a8095a4e
رقم الأكسشن: edsdoj.1fd6139a87124b14b3bf8ee5a8095a4e
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0036754