دورية أكاديمية
أعرض في EDS

Protein nanoparticle-induced osmotic pressure gradients modify pulmonary edema through hyperpermeability in acute respiratory distress syndrome

التفاصيل البيبلوغرافية
العنوان: Protein nanoparticle-induced osmotic pressure gradients modify pulmonary edema through hyperpermeability in acute respiratory distress syndrome
المؤلفون: ZhiZhi Qian, QianYi Wang, ZhaoShun Qiu, DanYang Li, ChenCheng Zhang, XiYu Xiong, ZiHui Zheng, QinLi Ruan, YiChen Guo, Jun Guo
المصدر: Journal of Nanobiotechnology, Vol 20, Iss 1, Pp 1-21 (2022)
بيانات النشر: BMC, 2022.
سنة النشر: 2022
المجموعة: LCC:Biotechnology
LCC:Medical technology
مصطلحات موضوعية: ARDS, Pulmonary edema, Protein nanoparticle-induced osmotic pressure, Voltage-dependent ion channels, Multi-targeted blockade, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5
الوصف: Abstract Acute respiratory distress syndrome (ARDS), caused by noncardiogenic pulmonary edema (PE), contributes significantly to Coronavirus 2019 (COVID-19)-associated morbidity and mortality. We explored the effect of transmembrane osmotic pressure (OP) gradients in PE using a fluorescence resonance energy transfer-based Intermediate filament (IF) tension optical probe. Angiotensin-II- and bradykinin-induced increases in intracellular protein nanoparticle (PN)-OP were associated with inflammasome production and cytoskeletal depolymerization. Intracellular protein nanoparticle production also resulted in cytomembrane hyperpolarization and L-VGCC-induced calcium signals, which differed from diacylglycerol-induced calcium increment via TRPC6 activation. Both pathways involve voltage-dependent cation influx and OP upregulation via SUR1-TRPM4 channels. Meanwhile, intra/extracellular PN-induced OP gradients across membranes upregulated pulmonary endothelial and alveolar barrier permeability. Attenuation of intracellular PN, calcium signals, and cation influx by drug combinations effectively relieved intracellular OP and pulmonary endothelial nonselective permeability, and improved epithelial fluid absorption and PE. Thus, PN-OP is pivotal in pulmonary edema in ARDS and COVID-19, and transmembrane OP recovery could be used to treat pulmonary edema and develop new drug targets in pulmonary injury. Graphical Abstract
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1477-3155
Relation: https://doaj.org/toc/1477-3155
DOI: 10.1186/s12951-022-01519-1
URL الوصول: https://doaj.org/article/1fd73f22605b4f668483b5824d1bb7f3
رقم الأكسشن: edsdoj.1fd73f22605b4f668483b5824d1bb7f3
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14773155
DOI:10.1186/s12951-022-01519-1