دورية أكاديمية
Alpinia oxyphylla Miq. Extract Prevents Diabetes in Mice by Modulating Gut Microbiota
| العنوان: | Alpinia oxyphylla Miq. Extract Prevents Diabetes in Mice by Modulating Gut Microbiota |
|---|---|
| المؤلفون: | Yiqiang Xie, Man Xiao, Yali Ni, Shangfei Jiang, Guizhu Feng, Shenggang Sang, Guankui Du |
| المصدر: | Journal of Diabetes Research, Vol 2018 (2018) |
| بيانات النشر: | Wiley, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Diseases of the endocrine glands. Clinical endocrinology |
| مصطلحات موضوعية: | Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| الوصف: | Recently, the role of gut microbiota in the development of obesity and type 2 diabetes mellitus (T2DM) has been highlighted. We performed an 8-week administration protocol on T2DM (C57BL/6J db-/db-) mice and fecal samples were collected. Comparisons of fecal bacterial communities were performed between db-/db- mice and normal mice (DB/DB) and between the db-/db mice treated and untreated with AOE using next-generation sequencing technology. Our results showed that the db-/db-AOE group had improved glycemic control and renal function compared with the db-/db-H2O group. Compared with the db-/db-H2O group, AOE administration resulted in significantly increased ratio of Bacteroidetes-to-Firmicutes in db-/db- mice. In addition, the abundance of Akkermansia was significantly increased, while Helicobacter was significantly suppressed in the db-/db-AOE group compared with the db-/db-H2O group. Our data suggest that AOE treatment decreased blood glucose levels and significantly reduced damage of renal pathology in the T2DM mice by modulating gut microbiota composition. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2314-6745 2314-6753 |
| Relation: | https://doaj.org/toc/2314-6745; https://doaj.org/toc/2314-6753 |
| DOI: | 10.1155/2018/4230590 |
| URL الوصول: | https://doaj.org/article/1ff03ae448a44b79a09778679b7455fa |
| رقم الأكسشن: | edsdoj.1ff03ae448a44b79a09778679b7455fa |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23146745 23146753 |
|---|---|
| DOI: | 10.1155/2018/4230590 |