دورية أكاديمية
أعرض في EDS

ErbB4 deletion in noradrenergic neurons in the locus coeruleus induces mania-like behavior via elevated catecholamines

التفاصيل البيبلوغرافية
العنوان: ErbB4 deletion in noradrenergic neurons in the locus coeruleus induces mania-like behavior via elevated catecholamines
المؤلفون: Shu-Xia Cao, Ying Zhang, Xing-Yue Hu, Bin Hong, Peng Sun, Hai-Yang He, Hong-Yan Geng, Ai-Min Bao, Shu-Min Duan, Jian-Ming Yang, Tian-Ming Gao, Hong Lian, Xiao-Ming Li
المصدر: eLife, Vol 7 (2018)
بيانات النشر: eLife Sciences Publications Ltd, 2018.
سنة النشر: 2018
المجموعة: LCC:Medicine
LCC:Science
LCC:Biology (General)
مصطلحات موضوعية: ErbB4, noradrenergic neuron, Locus coeruleus, mania, bipolar disorder, Medicine, Science, Biology (General), QH301-705.5
الوصف: Dysfunction of the noradrenergic (NE) neurons is implicated in the pathogenesis of bipolar disorder (BPD). ErbB4 is highly expressed in NE neurons, and its genetic variation has been linked to BPD; however, how ErbB4 regulates NE neuronal function and contributes to BPD pathogenesis is unclear. Here we find that conditional deletion of ErbB4 in locus coeruleus (LC) NE neurons increases neuronal spontaneous firing through NMDA receptor hyperfunction, and elevates catecholamines in the cerebrospinal fluid (CSF). Furthermore, Erbb4-deficient mice present mania-like behaviors, including hyperactivity, reduced anxiety and depression, and increased sucrose preference. These behaviors are completely rescued by the anti-manic drug lithium or antagonists of catecholaminergic receptors. Our study demonstrates the critical role of ErbB4 signaling in regulating LC-NE neuronal function, reinforcing the view that dysfunction of the NE system may contribute to the pathogenesis of mania-associated disorder.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2050-084X
Relation: https://elifesciences.org/articles/39907; https://doaj.org/toc/2050-084X
DOI: 10.7554/eLife.39907
URL الوصول: https://doaj.org/article/2005e053a6fe4f93850fd51c8ce022dd
رقم الأكسشن: edsdoj.2005e053a6fe4f93850fd51c8ce022dd
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:2050084X
DOI:10.7554/eLife.39907