دورية أكاديمية
A Survey on Association of P16 Protein and Uterine Cervical Dysplasia
| العنوان: | A Survey on Association of P16 Protein and Uterine Cervical Dysplasia |
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| المؤلفون: | Babak Izadi, Sedigheh Khazaei, Sayed Ghasem Mirbahari |
| المصدر: | مجله دانشکده پزشکی اصفهان, Vol 28, Iss 118, Pp 1207-1213 (2011) |
| بيانات النشر: | Isfahan University of Medical Sciences, 2011. |
| سنة النشر: | 2011 |
| المجموعة: | LCC:Medicine LCC:Medicine (General) |
| مصطلحات موضوعية: | Pap-Smear, Cervical dysplasia, Protein P16, Medicine, Medicine (General), R5-920 |
| الوصف: | Background: Cervical (uterine) carcinoma is the second most frequent type of women cancer. Success in early diagnosis of this disease is due to the use of pap-smear test. However, this test has both false-positive and false-negative results. P16 protein is a Cyclin-dependent Kinase inhibitor supposed to be overexpressed in cervical dysplasia and cancer. Our study was about correlation between P16 and cervical dysplasia. Methods: In this study 45 patients with dysplastic abnormalities in cervix (including Ascus-H) were sampled for papsmear (by Liquid-base method). Two smears were stained, one with papanicolau and the other (by IHC) for P16. The results were compared using t-test via SPSS15 software. Finding: Pap-stain revealed 13 ASCUS (29%), 18 LSIL (40%), 11 HSIL (24%), and 3 S.C.C (7%). Immunostaining of P16 protein was observed in ASCUS (3/13, 23%), LSIL (12/18, 67%), HSIL (11/11, 100%), and S.C.C (3/3, 100%). P16 had significant correlation with degree of cervical dysplasia in Liquid-base pap-smear (P < 0.0001). Conclusion: We suggest the usage of P16-test as an optional test for cervical dysplasia according to our study. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Persian |
| تدمد: | 1027-7595 1735-854X |
| Relation: | http://jims.mui.ac.ir/index.php/jims/article/view/579; https://doaj.org/toc/1027-7595; https://doaj.org/toc/1735-854X |
| URL الوصول: | https://doaj.org/article/200fb7ae7af04778835c70674389f168 |
| رقم الأكسشن: | edsdoj.200fb7ae7af04778835c70674389f168 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 10277595 1735854X |
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