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Selective targeting of mRNA and the following protein synthesis of CaMKIIα at the long-term potentiation-induced site

التفاصيل البيبلوغرافية
العنوان: Selective targeting of mRNA and the following protein synthesis of CaMKIIα at the long-term potentiation-induced site
المؤلفون: Itsuko Nihonmatsu, Noriaki Ohkawa, Yoshito Saitoh, Reiko Okubo-Suzuki, Kaoru Inokuchi
المصدر: Biology Open, Vol 9, Iss 1 (2020)
بيانات النشر: The Company of Biologists, 2020.
سنة النشر: 2020
المجموعة: LCC:Science
LCC:Biology (General)
مصطلحات موضوعية: camkiiα, camk2a mrna, dentate gyrus, hippocampus, local protein synthesis, long-term potentiation, Science, Biology (General), QH301-705.5
الوصف: Late-phase long-term potentiation (L-LTP) in hippocampus, thought to be the cellular basis of long-term memory, requires new protein synthesis. Neural activity enhances local protein synthesis in dendrites, which in turn mediates long-lasting synaptic plasticity. Ca2+/calmodulin-dependent protein kinase IIα (CaMKIIα) is a locally synthesized protein crucial for this plasticity, as L-LTP is impaired when its local synthesis is eliminated. However, the distribution of Camk2a mRNA during L-LTP induction remains unclear. In this study, we investigated the dendritic targeting of Camk2a mRNA after high-frequency stimulation, which induces L-LTP in synapses of perforant path and granule cells in the dentate gyrus in vivo. In situ hybridization studies revealed that Camk2a mRNA was immediately but transiently targeted to the site receiving high-frequency stimulation. This was associated with an increase in de novo protein synthesis of CaMKIIα. These results suggest that dendritic translation of CaMKIIα is locally mediated where L-LTP is induced. This phenomenon may be one of the essential processes for memory establishment.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2046-6390
Relation: http://bio.biologists.org/content/9/1/bio042861; https://doaj.org/toc/2046-6390
DOI: 10.1242/bio.042861
URL الوصول: https://doaj.org/article/202e2868e32b403889e25b9fec911306
رقم الأكسشن: edsdoj.202e2868e32b403889e25b9fec911306
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20466390
DOI:10.1242/bio.042861