دورية أكاديمية
أعرض في EDS

STAT3 expression is a prognostic marker in upper urinary tract urothelial carcinoma.

التفاصيل البيبلوغرافية
العنوان: STAT3 expression is a prognostic marker in upper urinary tract urothelial carcinoma.
المؤلفون: Kyosuke Matsuzaki, Kazutoshi Fujita, Yujiro Hayashi, Makoto Matsushita, Satoshi Nojima, Kentaro Jingushi, Taigo Kato, Atsunari Kawashima, Takeshi Ujike, Akira Nagahara, Motohide Uemura, Ryoichi Imamura, Seiji Yamaguchi, Hiroaki Fushimi, Hiroshi Miyamoto, Eiichi Morii, Norio Nonomura
المصدر: PLoS ONE, Vol 13, Iss 8, p e0201256 (2018)
بيانات النشر: Public Library of Science (PLoS), 2018.
سنة النشر: 2018
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Signal transducer and activator of transcription 3 (STAT3) plays a prominent role in the growth and invasion of several types of solid tumors. In this study, to assess the expression status and prognostic significance of the STAT3 pathway in upper urinary tract urothelial carcinoma (UTUC), we immunohistochemically stained for STAT3 and STAT3 pathway proteins, sphingosine-1-phosphate receptor 1 (S1PR1) and interleukin-6 (IL-6), in a tissue microarray containing 99 UTUC specimens. There were no significant associations between STAT3, S1PR1, or IL-6 expression pattern and tumor grade or pT stage. However, the patients with high STAT3 tumor had a significantly higher risk of both disease progression (p = 0.009) and cancer-specific mortality (p = 0.009), but not with tumors expressing S1PR1 or IL-6. High STAT3 expression in the nucleus was also associated with a significantly higher risk of both disease progression (p = 0.003) and cancer-specific mortality (p = 0.034). Multivariate analysis revealed that high STAT3 expression in the nucleus was significantly associated with cancer-specific survival after adjustment for pathological stage, lymph node involvement, lymphovascular invasion, and tumor grade (HR = 2.136, 95% CI = 1.009-4.767, p = 0.047). Our findings indicated that STAT3 could be a cancer-promoting factor and potentially a significant prognostic factor in UTUC.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC6084864?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0201256
URL الوصول: https://doaj.org/article/2043383dad53423eaef8c5ce0c20caf4
رقم الأكسشن: edsdoj.2043383dad53423eaef8c5ce0c20caf4
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0201256