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A Hypothesis: Hydrogen Sulfide Might Be Neuroprotective against Subarachnoid Hemorrhage Induced Brain Injury

التفاصيل البيبلوغرافية
العنوان: A Hypothesis: Hydrogen Sulfide Might Be Neuroprotective against Subarachnoid Hemorrhage Induced Brain Injury
المؤلفون: Yong-Peng Yu, Xiang-Lin Chi, Li-Jun Liu
المصدر: The Scientific World Journal, Vol 2014 (2014)
بيانات النشر: Wiley, 2014.
سنة النشر: 2014
المجموعة: LCC:Technology
LCC:Medicine
LCC:Science
مصطلحات موضوعية: Technology, Medicine, Science
الوصف: Gases such as nitric oxide (NO) and carbon monoxide (CO) play important roles both in normal physiology and in disease. Recent studies have shown that hydrogen sulfide (H2S) protects neurons against oxidative stress and ischemia-reperfusion injury and attenuates lipopolysaccharides (LPS) induced neuroinflammation in microglia, exhibiting anti-inflammatory and antiapoptotic activities. The gas H2S is emerging as a novel regulator of important physiologic functions such as arterial diameter, blood flow, and leukocyte adhesion. It has been known that multiple factors, including oxidative stress, free radicals, and neuronal nitric oxide synthesis as well as abnormal inflammatory responses, are involved in the mechanism underlying the brain injury after subarachnoid hemorrhage (SAH). Based on the multiple physiologic functions of H2S, we speculate that it might be a promising, effective, and specific therapy for brain injury after SAH.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2356-6140
1537-744X
Relation: https://doaj.org/toc/2356-6140; https://doaj.org/toc/1537-744X
DOI: 10.1155/2014/432318
URL الوصول: https://doaj.org/article/2082f2df8d2741e7a1ce4cce05d177d4
رقم الأكسشن: edsdoj.2082f2df8d2741e7a1ce4cce05d177d4
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:23566140
1537744X
DOI:10.1155/2014/432318