In cholestasis, due to impossibility of gall flow into duodenum, there occurs subsequent return of gall constituents to hepatocytes and circulation. Extrahepatic cholestasis is the result of mechanic obstacle of gall flow through ductus hepaticus, choledochus or papilla Vateri, leading to the occurrence of manifest icterus. In cases leading to liver damage, hydrophobic gall salts and non-conjugated bilirubins have the most important toxic effects. The aim of this study was to follow up biochemical parameters, enzyme activity gamma glutamyl transpeptidase (GGT) and alkaline phosphatase (AF), bilirubin concentration, total proteins and albumins in blood plasma in patients with different types of extrahepatic cholestasis.The study included 90 subjects divided into four groups. The first one was control, while the three other groups were formed according to the type of extrahepatic obstruction: the control group (20 healthy subjects), I group (20 patients with intraluminar extrahepatic obstruction –ILH), II group (20 patients with intraluminar obstruction-IMH), III group (30 patients with extraluminarly induced extrahepatic obstruction-ELH).Significant increase of activity of GGT and AF in plasma of cholestatic patients was present in comparison to the control group (p< 0,001). In plasma of cholestatic patients in the third group, GGT activity increased in comparison to the first group of patients (p
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