دورية أكاديمية
Circulating microRNAs and vascular calcification in hemodialysis patients
| العنوان: | Circulating microRNAs and vascular calcification in hemodialysis patients |
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| المؤلفون: | Chien-Te Lee, Yueh-Ting Lee, You-Lin Tain, Hwee-Yeong Ng, Wei-Hung Kuo |
| المصدر: | Journal of International Medical Research, Vol 47 (2019) |
| بيانات النشر: | SAGE Publishing, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Medicine (General) |
| مصطلحات موضوعية: | Medicine (General), R5-920 |
| الوصف: | Objective Vascular calcification is common in chronic dialysis patients and is associated with increased morbidity and mortality. However, the role of circulating microRNAs (miRs) in vascular calcification has rarely been investigated. We aimed to determine circulating levels of miRs in hemodialysis patients, and analyzed their relationship with vascular calcification. Methods Sixty-one stable hemodialysis patients were enrolled, including 31 with vascular calcification and 30 without. Demographic and biochemical data were collected and reviewed. The presence and severity of vascular calcification were determined by lumber spine X-ray. Blood levels of miR29a/b, miR223, miR9, and miR21 were determined. Results Patients with vascular calcification were older (65.6 ± 9.0 vs. 59.1 ± 7.1 years) with a higher proportion of vascular disease (55% vs. 23%) than those without vascular calcification. Additionally, high-sensitivity C-reactive protein (3.90 vs 2.09 mg/dL) and fibroblast growth factor 23 (17311 vs. 6306 pg/mL) were significantly higher. Patients with vascular calcification also had higher levels of miR29a/b and miR223. Regression analysis indicated that age and miR29a were significant associates of the calcification score. Conclusions Hemodialysis patients with vascular calcification had higher levels of miR 29a/b and miR223 than those without vascular calcification, and circulating miR29a was associated with calcification severity. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0300-0605 1473-2300 03000605 |
| Relation: | https://doaj.org/toc/0300-0605; https://doaj.org/toc/1473-2300 |
| DOI: | 10.1177/0300060519848949 |
| URL الوصول: | https://doaj.org/article/20c3ca9a101f4f6582ef18e4edff0093 |
| رقم الأكسشن: | edsdoj.20c3ca9a101f4f6582ef18e4edff0093 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 03000605 14732300 |
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| DOI: | 10.1177/0300060519848949 |