دورية أكاديمية
Mending a broken heart with novel cardiogenic small molecules
| العنوان: | Mending a broken heart with novel cardiogenic small molecules |
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| المؤلفون: | Nevan Powers, Guo N. Huang |
| المصدر: | Cell Regeneration, Vol 11, Iss 1, Pp 1-4 (2022) |
| بيانات النشر: | SpringerOpen, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine (General) LCC:Biology (General) |
| مصطلحات موضوعية: | Medicine (General), R5-920, Biology (General), QH301-705.5 |
| الوصف: | Abstract Adult mammalian cardiomyocytes are unable to proliferate to regenerate lost tissue after heart injury. Du et al., reporting in Cell Stem Cell, employ a FUCCI- and MADM-based system to screen for small molecules combinations that produced a collaborative effect on cardiomyocyte cycling and cytokinesis. The authors generate a cocktail of five small molecules that increase cardiomyocyte proliferation and regeneration in vitro and in vivo with high efficiency, and explore its potential in cardiac regenerative repair after myocardial infarction through a new potential pathway for cardiomyocyte cell-cycle re-entry. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-9769 |
| Relation: | https://doaj.org/toc/2045-9769 |
| DOI: | 10.1186/s13619-022-00120-z |
| URL الوصول: | https://doaj.org/article/d20da87b31c74f439290a3e26180c848 |
| رقم الأكسشن: | edsdoj.20da87b31c74f439290a3e26180c848 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 20459769 |
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| DOI: | 10.1186/s13619-022-00120-z |