دورية أكاديمية
Overflow phenomenon in serum lutein after supplementation: a systematic review supported with SNPs analyses
| العنوان: | Overflow phenomenon in serum lutein after supplementation: a systematic review supported with SNPs analyses |
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| المؤلفون: | Abdulrahman M Alharbi, Mohammed A Kilani, Tos TJM Berendschot |
| المصدر: | International Journal of Ophthalmology, Vol 14, Iss 7, Pp 1114-1119 (2021) |
| بيانات النشر: | Press of International Journal of Ophthalmology (IJO PRESS), 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Ophthalmology |
| مصطلحات موضوعية: | lutein, macular degeneration, carotenoids, xanthophylls, β-carotene dioxygenase, scavenger receptor class b type i, Ophthalmology, RE1-994 |
| الوصف: | Lutein, a type of carotenoids, is found to delay the onset and progression of age-related macular degeneration (AMD). Several lutein supplementation studies showed that after an initial increase, lutein serum levels demonstrated a subsequent decrease despite continuous supplementation. In this systematic literature review, this obscure phenomenon was tried to be explained. The subsequent drop in lutein levels was postulated due to down-regulation of lutein receptors scavenger receptor class B type I (SR-BI) in the gastrointestinal tract, upregulation of lutein degrading enzyme β-carotene dioxygenase (BCDO2), or perhaps a combination of both. Some single nucleotides polymorphisms (SNPs) that could have influence on the occurrence of this phenomenon. To date, an exact scientific explanation for this phenomenon has not been established. Further research is needed to investigate this phenomenon in depth to reach an irrefutable explanation, giving that lutein is proven to be effective in delaying the onset and progression of AMD and its metabolism in the human body becomes of equal importance. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2222-3959 2227-4898 |
| Relation: | http://ies.ijo.cn/en_publish/2021/7/20210722.pdf; https://doaj.org/toc/2222-3959; https://doaj.org/toc/2227-4898 |
| DOI: | 10.18240/ijo.2021.07.22 |
| URL الوصول: | https://doaj.org/article/20de72efe0684a60be1816cdf727d58e |
| رقم الأكسشن: | edsdoj.20de72efe0684a60be1816cdf727d58e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22223959 22274898 |
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| DOI: | 10.18240/ijo.2021.07.22 |