| الوصف: |
Eloisa de Sá Moreira,1 David Robinson,2 Stephanie Hawthorne,2 Linda Zhao,2 Madelyn Hanson,2 Gena Kanas,2 Matthew Turnure,2 Christine Davis,2 Otavio Clark2 1Health Division, Kantar, São Paulo, Brazil; 2Health Division, Kantar, New York, NY, USACorrespondence: Matthew TurnureKantar 175 Greenwich St, WTC 3, 35th Floor, New York, NY, 10007, USATel +1 314-221-4323Email matthew.turnure@Kantar.comPurpose: We describe patterns of care and treatment outcomes for non-metastatic PCa (nmPCA), either hormone-sensitive or castration-resistant, in the United States of America (USA) in 2018.Methods: A survey (CancerMPact®) recruited physicians nationwide to answer an online questionnaire about how they treated patients with nmPCA. Questions covered aspects of treatment at all disease stages. Board-certified urologists and oncologists with at least five years of clinical practice and who treated at least 30 PCa patients monthly were included.Results: The survey included responses from ninety-four physicians with an average of 17.5 years of clinical practice, who had treated a combined average of 4415 patients with nmPCA per month in 2018. Approximately 40% of patients in stage I were managed with either active surveillance or observation/no therapy, decreasing to 20%, 8% and 6% in stages II, III and IV(M0), respectively. Intensity-modulated radiotherapy was favored over other radiotherapy modalities, with rates of use ranging between 60% and 69% depending on disease stage. Leuprolide as monotherapy or in combination with enzalutamide, abiraterone or bicalutamide were the most common systemic treatment options for non-metastatic hormone-sensitive PCa (nmHSPC) patients with the first or second recurrence. Only 16.5% of non-metastatic castration-resistant PCa (nmCRPC) patients did not relapse within five years of initial therapy for nmCRPC.Conclusion: While PCa treatment recommendations are rapidly changing due to advances in treatment, we observed great concordance between their most current versions and real-world data treatment patterns reported by US physicians.Keywords: real-world evidence, treatment, physician reported, questionnaire |
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