دورية أكاديمية
Dysregulation of tRNA methylation in cancer: Mechanisms and targeting therapeutic strategies
العنوان: | Dysregulation of tRNA methylation in cancer: Mechanisms and targeting therapeutic strategies |
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المؤلفون: | Wenbin Yuan, Rui Zhang, Hao Lyu, Shuai Xiao, Dong Guo, Qi Zhang, Declan William Ali, Marek Michalak, Xing-Zhen Chen, Cefan Zhou, Jingfeng Tang |
المصدر: | Cell Death Discovery, Vol 10, Iss 1, Pp 1-19 (2024) |
بيانات النشر: | Nature Publishing Group, 2024. |
سنة النشر: | 2024 |
المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens LCC:Cytology |
مصطلحات موضوعية: | Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671 |
الوصف: | Abstract tRNA is the RNA type that undergoes the most modifications among known RNA, and in recent years, tRNA methylation has emerged as a crucial process in regulating gene translation. Dysregulation of tRNA abundance occurs in cancer cells, along with increased expression and activity of tRNA methyltransferases to raise the level of tRNA modification and stability. This leads to hijacking of translation and synthesis of multiple proteins associated with tumor proliferation, metastasis, invasion, autophagy, chemotherapy resistance, and metabolic reprogramming. In this review, we provide an overview of current research on tRNA methylation in cancer to clarify its involvement in human malignancies and establish a theoretical framework for future therapeutic interventions targeting tRNA methylation processes. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2058-7716 |
Relation: | https://doaj.org/toc/2058-7716 |
DOI: | 10.1038/s41420-024-02097-x |
URL الوصول: | https://doaj.org/article/214e79f3225840bc82f4e277c95c7812 |
رقم الأكسشن: | edsdoj.214e79f3225840bc82f4e277c95c7812 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 20587716 |
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DOI: | 10.1038/s41420-024-02097-x |