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Dysregulation of tRNA methylation in cancer: Mechanisms and targeting therapeutic strategies

التفاصيل البيبلوغرافية
العنوان: Dysregulation of tRNA methylation in cancer: Mechanisms and targeting therapeutic strategies
المؤلفون: Wenbin Yuan, Rui Zhang, Hao Lyu, Shuai Xiao, Dong Guo, Qi Zhang, Declan William Ali, Marek Michalak, Xing-Zhen Chen, Cefan Zhou, Jingfeng Tang
المصدر: Cell Death Discovery, Vol 10, Iss 1, Pp 1-19 (2024)
بيانات النشر: Nature Publishing Group, 2024.
سنة النشر: 2024
المجموعة: LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
LCC:Cytology
مصطلحات موضوعية: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671
الوصف: Abstract tRNA is the RNA type that undergoes the most modifications among known RNA, and in recent years, tRNA methylation has emerged as a crucial process in regulating gene translation. Dysregulation of tRNA abundance occurs in cancer cells, along with increased expression and activity of tRNA methyltransferases to raise the level of tRNA modification and stability. This leads to hijacking of translation and synthesis of multiple proteins associated with tumor proliferation, metastasis, invasion, autophagy, chemotherapy resistance, and metabolic reprogramming. In this review, we provide an overview of current research on tRNA methylation in cancer to clarify its involvement in human malignancies and establish a theoretical framework for future therapeutic interventions targeting tRNA methylation processes.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2058-7716
Relation: https://doaj.org/toc/2058-7716
DOI: 10.1038/s41420-024-02097-x
URL الوصول: https://doaj.org/article/214e79f3225840bc82f4e277c95c7812
رقم الأكسشن: edsdoj.214e79f3225840bc82f4e277c95c7812
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20587716
DOI:10.1038/s41420-024-02097-x