دورية أكاديمية
Titanium particles inhibit bone marrow mesenchymal stem cell osteogenic differentiation through the MAPK signaling pathway
| العنوان: | Titanium particles inhibit bone marrow mesenchymal stem cell osteogenic differentiation through the MAPK signaling pathway |
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| المؤلفون: | Shunyi Tong, Sanhua Fang, Kangjie Ying, Weiwei Chen |
| المصدر: | FEBS Open Bio, Vol 13, Iss 9, Pp 1699-1708 (2023) |
| بيانات النشر: | Wiley, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Biology (General) |
| مصطلحات موضوعية: | MAPK pathway, mesenchymal stem cell, osteogenic differentiation, Ti particles, Biology (General), QH301-705.5 |
| الوصف: | Metallic implants have great application in clinical orthopedics. Implants wear out in vivo due to long‐term mechanical loading. The formation of wear debris is one of the long‐term complications of prosthesis. In the case of artificial joint replacement in particular, aseptic loosening is the most common reason for secondary revision surgery. Previous studies suggested that wear debris caused aseptic loosening mainly by promoting osteolysis around the prosthesis. In this study, titanium particles, the most commonly used particles in clinical practice, were selected to simulate wear debris and explore the influence of titanium particles on osteogenic differentiation of mesenchymal stem cells. Our results show that titanium particles can significantly inhibit osteogenic differentiation in a dose‐dependent manner. While engaged in preliminary exploration of the underlying mechanisms, we found that titanium particles significantly affect phosphorylation of ERK1/2, a key component of MAPK signaling. This suggests that the MAPK signaling pathway is involved in the inhibition of osteogenic differentiation by titanium particles. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2211-5463 92233775 |
| Relation: | https://doaj.org/toc/2211-5463 |
| DOI: | 10.1002/2211-5463.13678 |
| URL الوصول: | https://doaj.org/article/21d7c394cd5b4ea98010b92233775d93 |
| رقم الأكسشن: | edsdoj.21d7c394cd5b4ea98010b92233775d93 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22115463 92233775 |
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| DOI: | 10.1002/2211-5463.13678 |