دورية أكاديمية
Human adipose tissue-derived MSCs improve psoriasis-like skin inflammation in mice by negatively regulating ROS
| العنوان: | Human adipose tissue-derived MSCs improve psoriasis-like skin inflammation in mice by negatively regulating ROS |
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| المؤلفون: | Feng Shi, Ling-Chuan Guo, Wei-Dong Zhu, Mei-Hong Cai, Ling-Ling Chen, Lei Wu, Xiao-Jian Chen, Hong-Yan Zhu, Jian Wu |
| المصدر: | Journal of Dermatological Treatment, Vol 33, Iss 4, Pp 2129-2136 (2022) |
| بيانات النشر: | Taylor & Francis Group, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Dermatology |
| مصطلحات موضوعية: | adipose tissue-derived mesenchymal stem cells, psoriasis, ros, Dermatology, RL1-803 |
| الوصف: | Background Psoriasis is chronic incurable skin inflammation. The anti-inflammatory properties of mesenchymal stem cells (MSCs) have been put forward to be involved in several inflammatory diseases. However, little was known about the role of human adipose tissue-derived stem cells (hAD-MSCs) in psoriasis. Objective We sought to explore the feasibility of using hAD-MSCs infusion as a therapeutic approach in psoriatic mice. Methods We constructed the psoriasis-like model by IMQ implication, treated with hAD-MSCs by subcutaneous injection. To evaluate the efficacy, we examined the histology, CD45 and ROS positive cells by HE and flow cytometry respectively. We also tested the key cytokines with PCR. Moreover, to achieve a better therapeutic effect, we treated the model by combing with vitamin E application. Results We found that the classic histological symptoms of psoriasis were relieved after treatment with hAD-MSCs, also, the splenic index, the infiltration of immune cells and several pro-inflammatory cytokines were decreased. Interestingly, we also found that hAD-MSCs could inhibit ROS generation. Moreover, the combination therapy of hAD-MSCs and vitamin E could promote the curative effect with greater ROS inhibition. Conclusion These results suggested that hAD-MSCs could be useful for treating psoriasis by negatively regulating ROS. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0954-6634 1471-1753 09546634 |
| Relation: | https://doaj.org/toc/0954-6634; https://doaj.org/toc/1471-1753 |
| DOI: | 10.1080/09546634.2021.1925622 |
| URL الوصول: | https://doaj.org/article/21e4c2b0710747cead043915328bd7f9 |
| رقم الأكسشن: | edsdoj.21e4c2b0710747cead043915328bd7f9 |
| قاعدة البيانات: | Directory of Open Access Journals |
PDF full text from Publisher | تدمد: | 09546634 14711753 |
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| DOI: | 10.1080/09546634.2021.1925622 |