دورية أكاديمية
Accelerated epigenetic age, inflammation, and gene expression in lung: comparisons of smokers and vapers with non-smokers
العنوان: | Accelerated epigenetic age, inflammation, and gene expression in lung: comparisons of smokers and vapers with non-smokers |
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المؤلفون: | Min-Ae Song, Kellie M. Mori, Joseph P. McElroy, Jo L. Freudenheim, Daniel Y. Weng, Sarah A. Reisinger, Theodore M. Brasky, Mark D. Wewers, Peter G. Shields |
المصدر: | Clinical Epigenetics, Vol 15, Iss 1, Pp 1-12 (2023) |
بيانات النشر: | BMC, 2023. |
سنة النشر: | 2023 |
المجموعة: | LCC:Medicine LCC:Genetics |
مصطلحات موضوعية: | Epigenetic aging, Biological aging, Vaping, Smoking, Gene expression, Inflammation, Medicine, Genetics, QH426-470 |
الوصف: | Abstract Background Cigarette smoking and aging are the main risk factors for pulmonary diseases, including cancer. Epigenetic aging may explain the relationship between smoking, electronic cigarette vaping, and pulmonary health. No study has examined smoking and vaping-related epigenetic aging in relation to lung biomarkers. Methods Lung epigenetic aging measured by DNA methylation (mAge) and its acceleration (mAA) was assessed in young (age 21–30) electronic cigarette vapers (EC, n = 14, including 3 never-smoking EC), smokers (SM, n = 16), and non-EC/non-SM (NS, n = 39). We investigated relationships of mAge estimates with chronological age (Horvath-mAge), lifespan/mortality (Grim-mAge), telomere length (TL-mAge), smoking/EC history, urinary biomarkers, lung cytokines, and transcriptome. Results Compared to NS, EC and SM had significantly older Grim-mAge, shorter TL-mAge, significantly accelerated Grim-mAge and decelerated TL-mAge. Among SM, Grim-mAA was associated with nicotine intake and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL). For EC, Horvath-mAA was significantly correlated with puffs per day. Overall, cytokines (IL-1β, IL-6, and IL-8) and 759 transcripts (651 unique genes) were significantly associated with Grim-mAA. Grim-mAA-associated genes were highly enriched in immune-related pathways and genes that play a role in the morphology and structures of cells/tissues. Conclusions Faster lung mAge for SM is consistent with prior studies of blood. Faster lung mAge for EC compared to NS indicates possible adverse pulmonary effects of EC on biological aging. Our findings support further research, particularly on epigenetic markers, on effects of smoking and vaping on pulmonary health. Given that most EC are former smokers, further study is needed to understand unique effects of electronic cigarettes on biological aging. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1868-7083 |
Relation: | https://doaj.org/toc/1868-7083 |
DOI: | 10.1186/s13148-023-01577-8 |
URL الوصول: | https://doaj.org/article/21f2f1b269dd4f138393216a2b4f7964 |
رقم الأكسشن: | edsdoj.21f2f1b269dd4f138393216a2b4f7964 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 18687083 |
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DOI: | 10.1186/s13148-023-01577-8 |