دورية أكاديمية
Nigella sativa in Comparison to Steroids in Managing Oral Submucous Fibrosis
| العنوان: | Nigella sativa in Comparison to Steroids in Managing Oral Submucous Fibrosis |
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| المؤلفون: | Hira Batool, Mervyn Hosein, Saima Akram Butt, Shafaq Saeed Roghay, Akhtar Ali, Fizza Abidi |
| المصدر: | Pakistan Journal of Medicine and Dentistry, Vol 11, Iss 2 (2024) |
| بيانات النشر: | ziauddin University, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Biochemistry LCC:Dentistry LCC:Therapeutics. Pharmacology LCC:Medicine (General) |
| مصطلحات موضوعية: | Biochemistry, QD415-436, Dentistry, RK1-715, Therapeutics. Pharmacology, RM1-950, Medicine (General), R5-920 |
| الوصف: | Background: Nigella sativa (N. sativa), a natural herb, commonly known as Black seed or Kalonji, has a prolonged medicinal history of more than 2000 years. Oral submucous fibrosis (OSMF) is a chronic inflammatory disorder, which is mostly treated with steroids. This clinical trial was conducted to assess the effectiveness of N. sativa oil in comparison to steroids for treating OSMF. Methods: This randomized clinical trial consisted of n=39 clinically diagnosed OSMF patients aged 18 years and above. Patients were divided through randomization into two groups. Group 1 was prescribed steroid lotion while Group 2 was given N. sativa oil (Cold-pressed) to be applied on the buccal mucosa for three months along with physiotherapy. Mann-Whitney U Test while the Wilcoxon Rank sum test were applied. A p-value of less than 0.05 was considered statistically significant. Results: Thirty patients (aged 35.33±2.07) completed the trial in which the majority were males (n=28, 93.30%) and were from Urdu-speaking communities [22 (73.30%)]. Most of the patients (n= 18, 60%) were consuming a combination of Pan and Areca Nut (Chaliya), 04 (13.3%) were consuming only areca nut while 03 (10%) used Gutkha as a habit. In this trial, N. sativa was found to be equally effective as compared to steroids in reducing pain and improving the interincisal mouth opening (IIMO) (p-value >0.05%). Conclusion: N. sativa can be used as an effective treatment option for reducing pain or burning and increasing interincisal mouth opening in patients with OSMF without producing any side effects. Keywords: Nigella sativa; Oral Submucous Fibrosis; Steroids; Head and Neck Squamous Cell Carcinoma. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2313-7371 2308-2593 |
| Relation: | https://ojs.zu.edu.pk/pjmd/article/view/1554; https://doaj.org/toc/2313-7371; https://doaj.org/toc/2308-2593 |
| DOI: | 10.36283/PJMD11-2/008 |
| URL الوصول: | https://doaj.org/article/220600e661f54c0d947b6c37c25783ca |
| رقم الأكسشن: | edsdoj.220600e661f54c0d947b6c37c25783ca |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23137371 23082593 |
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| DOI: | 10.36283/PJMD11-2/008 |