دورية أكاديمية
أعرض في EDS

High levels of high-sensitivity C-reactive protein and uric acid can predict disease severity in patients with mitral regurgitation

التفاصيل البيبلوغرافية
العنوان: High levels of high-sensitivity C-reactive protein and uric acid can predict disease severity in patients with mitral regurgitation
المؤلفون: Yasin Turker, Ismail Ekinozu, Yasemin Turker, Mehmet Akkaya
المصدر: Revista Portuguesa de Cardiologia, Vol 33, Iss 11, Pp 699-706 (2014)
بيانات النشر: Elsevier, 2014.
سنة النشر: 2014
المجموعة: LCC:Diseases of the circulatory (Cardiovascular) system
مصطلحات موضوعية: Diseases of the circulatory (Cardiovascular) system, RC666-701
الوصف: Introduction: Both high-sensitivity CRP (hs-CRP) and uric acid (UA) levels are known to be increased in heart failure patients and are associated with poorer functional capacity and adverse outcome. The role of these markers in patients with mitral regurgitation (MR) is less clear. The aim of this study was to assess the relationship between hs-CRP, UA and organic MR. We also assessed whether hs-CRP and UA levels are correlated with symptoms of MR, severity of MR, LV remodeling and outcome during follow-up. Methods: A total of 200 consecutive patients (87 men [43.5%]; mean age 61.6±12.5 years) with moderate or severe isolated and organic MR were included in the study. All the patients were assessed clinically and were managed and treated with standard medical therapy according to evidence-based practice guidelines. Patients were categorized according to New York Heart Association (NYHA) functional class. We assessed and graded the severity of MR using a multiparametric approach. hs-CRP was measured with chemiluminescent immunometric assay using an IMMULITE® 1000 autoanalyzer (Siemens, Germany). Serum UA levels were analyzed using a Cobas® 6000 autoanalyzer (Roche Diagnostics, Mannheim, Germany). Results: Mean UA levels increased significantly with NYHA class: 4.46±1.58 mg/dl for patients in NYHA class I, 5.91±1.69 mg/dl for class II, 6.31±2.16 mg/dl for class III and 8.86±3.17 mg/dl for class IV (p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
Portuguese
تدمد: 0870-2551
Relation: http://www.sciencedirect.com/science/article/pii/S0870255114002558; https://doaj.org/toc/0870-2551
DOI: 10.1016/j.repc.2014.03.014
URL الوصول: https://doaj.org/article/2231ac6038364403be315e0ca033a5d8
رقم الأكسشن: edsdoj.2231ac6038364403be315e0ca033a5d8
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:08702551
DOI:10.1016/j.repc.2014.03.014