دورية أكاديمية
Baicalin-aluminum complex on the regulation of IPEC-1 infected with enterotoxigenic Escherichia coli
| العنوان: | Baicalin-aluminum complex on the regulation of IPEC-1 infected with enterotoxigenic Escherichia coli |
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| المؤلفون: | Chun Ye, Yuqian Chen, Ruixue Yu, Ming Zhao, Ronghua Yin, Yinsheng Qiu, Shulin Fu, Yu Liu, Zhongyuan Wu |
| المصدر: | Heliyon, Vol 10, Iss 12, Pp e33038- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Science (General) LCC:Social sciences (General) |
| مصطلحات موضوعية: | Baicalin-aluminum complex, Diarrhea, Enterotoxigenic Escherichia coli, IPEC-1, Piglet, Science (General), Q1-390, Social sciences (General), H1-99 |
| الوصف: | Enterotoxigenic Escherichia coli (ETEC) is the main bacterial cause of diarrhea in weaned piglets. Baicalin-aluminum (BA) complex is the main active ingredient of Scutellaria baicalensis Georgi extracted-aluminum complex, which has been used to treat diarrhea in weaning piglets, however the underlying mechanism remains unclear. To investigate the effects of the BA complex on the regulation of porcine intestinal epithelial (IPEC-1) cells infected with ETEC, IPEC-1 cells were incubated with an ETEC bacterial strain at a multiplicity of infection of 1 for 6 h and then treated with different concentrations of the BA complex for 6 h. ETEC infection increased the levels of cAMP and cGMP, upregulated CFTR (cystic fibrosis transmembrane conductance regulator) mRNA, and downregulated NHE4 mRNA in IPEC-1 cells. Treatment with the BA complex inhibited ETEC adhesion and the production of cAMP and cGMP, reduced CFTR mRNA expression, and increased NHE4 mRNA expression. Overall, the BA complex weakened the adhesion of ETEC to IPEC-1 cells, and inhibited cAMP/cGMP-CFTR signaling in IPEC-1 cells. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2405-8440 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2405844024090698; https://doaj.org/toc/2405-8440 |
| DOI: | 10.1016/j.heliyon.2024.e33038 |
| URL الوصول: | https://doaj.org/article/22330ff7c8da4764b03d1651b66976b7 |
| رقم الأكسشن: | edsdoj.22330ff7c8da4764b03d1651b66976b7 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24058440 |
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| DOI: | 10.1016/j.heliyon.2024.e33038 |