دورية أكاديمية
Efficacy of HIVEC in patients with high-risk non-muscle invasive bladder cancer who are contraindicated to BCG and in patients who fail BCG therapy
| العنوان: | Efficacy of HIVEC in patients with high-risk non-muscle invasive bladder cancer who are contraindicated to BCG and in patients who fail BCG therapy |
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| المؤلفون: | Laure Doisy, Arnaud Cimier, Aurélien Adypagavane, Jochen Walz, Thibault Marquette, Thomas Maubon, Stanislas Rybikowski, Sami Fakhfakh, Kevin Loverde, Nicolas Mottet, Jacques Irani, Eric Lechevallier, Dominique Rossi, Gwenaelle Gravis, Géraldine Pignot |
| المصدر: | International Journal of Hyperthermia, Vol 38, Iss 1, Pp 1633-1638 (2021) |
| بيانات النشر: | Taylor & Francis Group, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medical technology |
| مصطلحات موضوعية: | bladder cancer, bcg-refractory, cystectomy, chemohyperthermia, recurrence, progression, Medical technology, R855-855.5 |
| الوصف: | Purpose To evaluate Hyperthermic-Intra-Vesical Chemotherapy (HIVEC) efficacy regarding 1-year disease-free survival (RFS) rate and bladder preservation rate in patients with High-risk Non-Muscle Invasive Bladder Cancer (NMIBC) who fail BCG therapy or are contraindicated to BCG. Methods Between June 2016 and October 2019, patients treated with HIVEC for mostly high-risk NMIBC who failed BCG or BCG-naive if BCG contraindicated have been included in our study. These patients had a theoretical indication for cystectomy but were ineligible for surgery or refused it. Results Fifty-three patients, median age 72 [39–93] years, were included in this study (n = 29 BCG-failure and n = 24 BCG-naive). The median follow-up was 18 months. The bladder preservation rate was 92.4%. The 12 months-RFS rate was 60.5%. The RFS rates for BCG-naive and BCG-failure groups were respectively 70% and 52.2% at 12 months. Three patients progressed to muscle infiltration, all in the BCG-failure group and all in the very high-risk EORTC group. Two of them developed metastatic disease and died from bladder cancer. Conclusion Chemohyperthermia using HIVEC achieved a RFS rate of 60% at 1 year and enabled a bladder preservation rate of 92%. Given the low risk of progression in the BCG-naive group, HIVEC could be a good alternative. Conversely, for patients with very high-risk tumors that fail BCG, cystectomy should remain the standard of care and HIVEC may be discussed cautiously for patients who are not eligible for surgery and well informed of the risk of progression to muscle-invasive disease. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0265-6736 1464-5157 02656736 |
| Relation: | https://doaj.org/toc/0265-6736; https://doaj.org/toc/1464-5157 |
| DOI: | 10.1080/02656736.2021.2002435 |
| URL الوصول: | https://doaj.org/article/2244ac07f40049d88cd6f64b4d121df2 |
| رقم الأكسشن: | edsdoj.2244ac07f40049d88cd6f64b4d121df2 |
| قاعدة البيانات: | Directory of Open Access Journals |
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Full Text Finder | تدمد: | 02656736 14645157 |
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| DOI: | 10.1080/02656736.2021.2002435 |