دورية أكاديمية
Healthcare Resource Use and Costs Associated with Organ Damage in Newly Diagnosed Adults with Systemic Lupus Erythematosus in the UK
| العنوان: | Healthcare Resource Use and Costs Associated with Organ Damage in Newly Diagnosed Adults with Systemic Lupus Erythematosus in the UK |
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| المؤلفون: | Heide A. Stirnadel-Farrant, Sarowar M. Golam, Barbara Naisbett-Groet, Danny Gibson, Julia Langham, Sue Langham, Mihail Samnaliev |
| المصدر: | Rheumatology and Therapy, Vol 10, Iss 5, Pp 1183-1197 (2023) |
| بيانات النشر: | Adis, Springer Healthcare, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Diseases of the musculoskeletal system |
| مصطلحات موضوعية: | Costs, Healthcare resource use, Organ damage, Systemic lupus erythematosus, Diseases of the musculoskeletal system, RC925-935 |
| الوصف: | Abstract Introduction This analysis compared healthcare resource use (HCRU) and costs associated with incident organ damage in a cohort of adult patients with systemic lupus erythematosus (SLE). Methods Incident SLE cases were identified (Clinical Practice Research Datalink [CPRD] and Hospital Episode Statistics-linked healthcare databases; January 1, 2005–June 30, 2019). Annual incidence of 13 organ damage domains was calculated from SLE diagnosis through follow-up. Annualized HCRU and costs were compared between organ damage and non-organ damage patient groups using generalized estimating equations. Results A total of 936 patients met the inclusion criteria for SLE. Mean age was 48.0 (standard deviation [SD] 15.7) years and 88% were female. Over a median follow-up period of 4.3 (interquartile range [IQR] 1.9–7.0) years, 59% (315/533) had evidence of post-SLE diagnosis incident organ damage (≥ 1 type), which was greatest for musculoskeletal (146/819 [18%]), cardiovascular (149/842 [18%]), and skin (148/856 [17%]) domains. Patients with organ damage had greater resource use for all organ systems, excluding gonadal, versus those without it. Overall, mean (SD) annualized all-cause HCRU was greater in patients with organ damage versus those without it (inpatient, 1.0 versus 0.2; outpatient, 7.3 versus 3.5; accident and emergency, 0.5 versus 0.2 days; primary care contacts, 28.7 versus 16.5; prescription medications, 62.3 versus 22.9). Adjusted mean annualized all-cause costs were significantly greater in both post- and pre-organ damage index periods for patients with organ damage versus those without it (all P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2198-6576 2198-6584 |
| Relation: | https://doaj.org/toc/2198-6576; https://doaj.org/toc/2198-6584 |
| DOI: | 10.1007/s40744-023-00567-9 |
| URL الوصول: | https://doaj.org/article/225ac143668d4ac5a190ba3d0c663488 |
| رقم الأكسشن: | edsdoj.225ac143668d4ac5a190ba3d0c663488 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 21986576 21986584 |
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| DOI: | 10.1007/s40744-023-00567-9 |