دورية أكاديمية

Fibrin degradation products and survival in patients with chronic obstructive pulmonary disease: a protocolized prospective observational study

التفاصيل البيبلوغرافية
العنوان: Fibrin degradation products and survival in patients with chronic obstructive pulmonary disease: a protocolized prospective observational study
المؤلفون: Peter Kamstrup, Pradeesh Sivapalan, Christian Rønn, Ema Rastoder, Daniel Modin, Anna Kjaer Kristensen, Elisabeth Bendstrup, Rikke Sørensen, Tor Biering-Sørensen, Charlotte Suppli Ulrik, Jørgen Vestbo, Jens-Ulrik Jensen
المصدر: Respiratory Research, Vol 24, Iss 1, Pp 1-10 (2023)
بيانات النشر: BMC, 2023.
سنة النشر: 2023
المجموعة: LCC:Diseases of the respiratory system
مصطلحات موضوعية: Cohort, D-dimer, COPD, Biomarker, All-cause mortality, Diseases of the respiratory system, RC705-779
الوصف: Abstract Background Patients with chronic obstructive pulmonary disease (COPD) have a high incidence of cardiovascular disease including thromboembolisms. Fibrin degradation products, like D-dimer, have been associated with death from all causes in healthy individuals and COPD patients. We aimed to determine the (i) association between D-dimer levels and all-cause mortality and time being alive and out of a hospital, (ii) possible modifying effect of anticoagulant treatment,, and (iii) distribution of D-dimer in patients with moderate to severe COPD. Methods Results of routinely measured stable phase D-dimer samples from COPD-outpatients at Copenhagen University Hospital – Herlev and Gentofte, COPD-outpatient clinic were collected using the Danish registries. These were used to examine whether COPD-patients with a D-dimer level in the upper quartile, had a higher risk of death from all causes within 365 days. Results In the unadjusted Cox proportional hazards regression we found an association between high D-dimer and all-cause mortality: Hazard ratio (HR): 2.3 (95% Confidence Interval (CI) 1.1–4.7). In the fully adjusted regression, the HR was 1.8 (CI 0.8–3.9). We did not find any interaction between D-dimer and anticoagulant or antiplatelet therapy. For the secondary outcome, proportion of days alive and out of hospital in 365 days (pDAOH), the unadjusted multiple linear regression had an association between high D-dimer level and pDAOH: -2.7% points (pp) (CI -3.9 pp - -1.5 pp), which was attenuated to -1,7pp (-2.9pp – -0.4pp) in the fully adjusted regression. Conclusions In patients with moderate to severe COPD, patients with a high level of D-dimer were more likely to die; however, the signal was not strong in the adjusted analyses and our results do not support unselected risk stratification with D-dimer in COPD-outpatients.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1465-993X
Relation: https://doaj.org/toc/1465-993X
DOI: 10.1186/s12931-023-02472-9
URL الوصول: https://doaj.org/article/22a15c774cd34f1ca0fb4b0d798277b1
رقم الأكسشن: edsdoj.22a15c774cd34f1ca0fb4b0d798277b1
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:1465993X
DOI:10.1186/s12931-023-02472-9