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Transcriptome analysis reveals organ-specific effects of 2-deoxyglucose treatment in healthy mice.

التفاصيل البيبلوغرافية
العنوان: Transcriptome analysis reveals organ-specific effects of 2-deoxyglucose treatment in healthy mice.
المؤلفون: Ann E Wells, John J Wilson, Sarah E Heuer, John D Sears, Jian Wei, Raghav Pandey, Mauro W Costa, Catherine C Kaczorowski, Derry C Roopenian, Chih-Hao Chang, Gregory W Carter
المصدر: PLoS ONE, Vol 19, Iss 3, p e0299595 (2024)
بيانات النشر: Public Library of Science (PLoS), 2024.
سنة النشر: 2024
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: ObjectiveGlycolytic inhibition via 2-deoxy-D-glucose (2DG) has potential therapeutic benefits for a range of diseases, including cancer, epilepsy, systemic lupus erythematosus (SLE), and rheumatoid arthritis (RA), and COVID-19, but the systemic effects of 2DG on gene function across different tissues are unclear.MethodsThis study analyzed the transcriptional profiles of nine tissues from C57BL/6J mice treated with 2DG to understand how it modulates pathways systemically. Principal component analysis (PCA), weighted gene co-network analysis (WGCNA), analysis of variance, and pathway analysis were all performed to identify modules altered by 2DG treatment.ResultsPCA revealed that samples clustered predominantly by tissue, suggesting that 2DG affects each tissue uniquely. Unsupervised clustering and WGCNA revealed six distinct tissue-specific modules significantly affected by 2DG, each with unique key pathways and genes. 2DG predominantly affected mitochondrial metabolism in the heart, while in the small intestine, it affected immunological pathways.ConclusionsThese findings suggest that 2DG has a systemic impact that varies across organs, potentially affecting multiple pathways and functions. The study provides insights into the potential therapeutic benefits of 2DG across different diseases and highlights the importance of understanding its systemic effects for future research and clinical applications.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0299595&type=printable; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0299595&type=printable
DOI: 10.1371/journal.pone.0299595
URL الوصول: https://doaj.org/article/22ce3f406d0c4edab2420289fe6e8a30
رقم الأكسشن: edsdoj.22ce3f406d0c4edab2420289fe6e8a30
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0299595&type=printable