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Absolute leukocyte telomere length in HIV-infected and uninfected individuals: evidence of accelerated cell senescence in HIV-associated chronic obstructive pulmonary disease.

التفاصيل البيبلوغرافية
العنوان: Absolute leukocyte telomere length in HIV-infected and uninfected individuals: evidence of accelerated cell senescence in HIV-associated chronic obstructive pulmonary disease.
المؤلفون: Joseph C Y Liu, Janice M Leung, David A Ngan, Negar F Nashta, Silvia Guillemi, Marianne Harris, Viviane D Lima, Soo-Jung Um, Yuexin Li, Sheena Tam, Tawimas Shaipanich, Rekha Raju, Cameron Hague, Jonathon A Leipsic, Jean Bourbeau, Wan C Tan, P Richard Harrigan, Don D Sin, Julio Montaner, S F Paul Man
المصدر: PLoS ONE, Vol 10, Iss 4, p e0124426 (2015)
بيانات النشر: Public Library of Science (PLoS), 2015.
سنة النشر: 2015
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Combination antiretroviral therapy (cART) has extended the longevity of human immunodeficiency virus (HIV)-infected individuals. However, this has resulted in greater awareness of age-associated diseases such as chronic obstructive pulmonary disease (COPD). Accelerated cellular senescence may be responsible, but its magnitude as measured by leukocyte telomere length is unknown and its relationship to HIV-associated COPD has not yet been established. We measured absolute telomere length (aTL) in peripheral leukocytes from 231 HIV-infected adults. Comparisons were made to 691 HIV-uninfected individuals from a population-based sample. Subject quartiles of aTL were assessed for relationships with measures of HIV disease severity, airflow obstruction, and emphysema severity on computed tomographic (CT) imaging. Multivariable regression models identified factors associated with shortened aTL. Compared to HIV-uninfected subjects, the mean aTL in HIV-infected patients was markedly shorter by 27 kbp/genome (p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC4401786?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0124426
URL الوصول: https://doaj.org/article/22f2527415964f1681711056667cf0a5
رقم الأكسشن: edsdoj.22f2527415964f1681711056667cf0a5
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0124426