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Evaluation of surface-based hippocampal registration using ground-truth subfield definitions

التفاصيل البيبلوغرافية
العنوان: Evaluation of surface-based hippocampal registration using ground-truth subfield definitions
المؤلفون: Jordan DeKraker, Nicola Palomero-Gallagher, Olga Kedo, Neda Ladbon-Bernasconi, Sascha EA Muenzing, Markus Axer, Katrin Amunts, Ali R Khan, Boris C Bernhardt, Alan C Evans
المصدر: eLife, Vol 12 (2023)
بيانات النشر: eLife Sciences Publications Ltd, 2023.
سنة النشر: 2023
المجموعة: LCC:Medicine
LCC:Science
LCC:Biology (General)
مصطلحات موضوعية: hippocampal subfields, histology, MRI, visualization, image registration, Medicine, Science, Biology (General), QH301-705.5
الوصف: The hippocampus is an archicortical structure, consisting of subfields with unique circuits. Understanding its microstructure, as proxied by these subfields, can improve our mechanistic understanding of learning and memory and has clinical potential for several neurological disorders. One prominent issue is how to parcellate, register, or retrieve homologous points between two hippocampi with grossly different morphologies. Here, we present a surface-based registration method that solves this issue in a contrast-agnostic, topology-preserving manner. Specifically, the entire hippocampus is first analytically unfolded, and then samples are registered in 2D unfolded space based on thickness, curvature, and gyrification. We demonstrate this method in seven 3D histology samples and show superior alignment with respect to subfields using this method over more conventional registration approaches.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2050-084X
Relation: https://elifesciences.org/articles/88404; https://doaj.org/toc/2050-084X
DOI: 10.7554/eLife.88404
URL الوصول: https://doaj.org/article/d230b034d31e4d0480708d6fdfb5d52a
رقم الأكسشن: edsdoj.230b034d31e4d0480708d6fdfb5d52a
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:2050084X
DOI:10.7554/eLife.88404