دورية أكاديمية
Epigenetic reprogramming during the maternal‐to‐zygotic transition
| العنوان: | Epigenetic reprogramming during the maternal‐to‐zygotic transition |
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| المؤلفون: | Yurong Chen, Luyao Wang, Fucheng Guo, Xiangpeng Dai, Xiaoling Zhang |
| المصدر: | MedComm, Vol 4, Iss 4, Pp n/a-n/a (2023) |
| بيانات النشر: | Wiley, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | chromatin, embryo development, epigenetics, MZT, reprogramming, ZGA, Medicine |
| الوصف: | Abstract After fertilization, sperm and oocyte fused and gave rise to a zygote which is the beginning of a new life. Then the embryonic development is monitored and regulated precisely from the transition of oocyte to the embryo at the early stage of embryogenesis, and this process is termed maternal‐to‐zygotic transition (MZT). MZT involves two major events that are maternal components degradation and zygotic genome activation. The epigenetic reprogramming plays crucial roles in regulating the process of MZT and supervising the normal development of early development of embryos. In recent years, benefited from the rapid development of low‐input epigenome profiling technologies, new epigenetic modifications are found to be reprogrammed dramatically and may play different roles during MZT whose dysregulation will cause an abnormal development of embryos even abortion at various stages. In this review, we summarized and discussed the important novel findings on epigenetic reprogramming and the underlying molecular mechanisms regulating MZT in mammalian embryos. Our work provided comprehensive and detailed references for the in deep understanding of epigenetic regulatory network in this key biological process and also shed light on the critical roles for epigenetic reprogramming on embryonic failure during artificial reproductive technology and nature fertilization. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2688-2663 23232293 |
| Relation: | https://doaj.org/toc/2688-2663 |
| DOI: | 10.1002/mco2.331 |
| URL الوصول: | https://doaj.org/article/23232293bb2c4783a95a2b37203c6e42 |
| رقم الأكسشن: | edsdoj.23232293bb2c4783a95a2b37203c6e42 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 26882663 23232293 |
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| DOI: | 10.1002/mco2.331 |