دورية أكاديمية
Integrative Neuroinformatics for Precision Prognostication and Personalized Therapeutics in Moderate and Severe Traumatic Brain Injury
| العنوان: | Integrative Neuroinformatics for Precision Prognostication and Personalized Therapeutics in Moderate and Severe Traumatic Brain Injury |
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| المؤلفون: | Frederick A. Zeiler, Yasser Iturria-Medina, Eric P. Thelin, Alwyn Gomez, Jai J. Shankar, Ji Hyun Ko, Chase R. Figley, Galen E. B. Wright, Chris M. Anderson |
| المصدر: | Frontiers in Neurology, Vol 12 (2021) |
| بيانات النشر: | Frontiers Media S.A., 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Neurology. Diseases of the nervous system |
| مصطلحات موضوعية: | multi-modal data, neuroinformatics, precision medicine, traumatic brain injury, big data, Neurology. Diseases of the nervous system, RC346-429 |
| الوصف: | Despite changes in guideline-based management of moderate/severe traumatic brain injury (TBI) over the preceding decades, little impact on mortality and morbidity have been seen. This argues against the “one-treatment fits all” approach to such management strategies. With this, some preliminary advances in the area of personalized medicine in TBI care have displayed promising results. However, to continue transitioning toward individually-tailored care, we require integration of complex “-omics” data sets. The past few decades have seen dramatic increases in the volume of complex multi-modal data in moderate and severe TBI care. Such data includes serial high-fidelity multi-modal characterization of the cerebral physiome, serum/cerebrospinal fluid proteomics, admission genetic profiles, and serial advanced neuroimaging modalities. Integrating these complex and serially obtained data sets, with patient baseline demographics, treatment information and clinical outcomes over time, can be a daunting task for the treating clinician. Within this review, we highlight the current status of such multi-modal omics data sets in moderate/severe TBI, current limitations to the utilization of such data, and a potential path forward through employing integrative neuroinformatic approaches, which are applied in other neuropathologies. Such advances are positioned to facilitate the transition to precision prognostication and inform a top-down approach to the development of personalized therapeutics in moderate/severe TBI. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1664-2295 85974013 |
| Relation: | https://www.frontiersin.org/articles/10.3389/fneur.2021.729184/full; https://doaj.org/toc/1664-2295 |
| DOI: | 10.3389/fneur.2021.729184 |
| URL الوصول: | https://doaj.org/article/2356017c859740138a4a2265656359c2 |
| رقم الأكسشن: | edsdoj.2356017c859740138a4a2265656359c2 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16642295 85974013 |
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| DOI: | 10.3389/fneur.2021.729184 |