دورية أكاديمية
Theragnostic application of nanoparticle and CRISPR against food-borne multi-drug resistant pathogens
| العنوان: | Theragnostic application of nanoparticle and CRISPR against food-borne multi-drug resistant pathogens |
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| المؤلفون: | Rahul Bhattacharjee, Aditya Nandi, Priya Mitra, Koustav Saha, Paritosh Patel, Ealisha Jha, Pritam Kumar Panda, Sushil Kumar Singh, Ateet Dutt, Yogendra Kumar Mishra, Suresh K. Verma, Mrutyunjay Suar |
| المصدر: | Materials Today Bio, Vol 15, Iss , Pp 100291- (2022) |
| بيانات النشر: | Elsevier, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine (General) LCC:Biology (General) |
| مصطلحات موضوعية: | Antimicrobial activity, Diagnosis, CRISPR-Cas system, Nanoparticle and MDR food-Borne- pathogens, Medicine (General), R5-920, Biology (General), QH301-705.5 |
| الوصف: | Foodborne infection is one of the leading sources of infections spreading across the world. Foodborne pathogens are recognized as multidrug-resistant (MDR) pathogens posing a significant problem in the food industry and healthy consumers resulting in enhanced economic burden, and nosocomial infections. The continued search for enhanced microbial detection tools has piqued the interest of the CRISPR-Cas system and Nanoparticles. CRISPR-Cas system is present in the bacterial genome of some prokaryotes and is repurposed as a theragnostic tool against MDR pathogens. Nanoparticles and composites have also emerged as an efficient tool in theragnostic applications against MDR pathogens. The diagnostic limitations of the CRISPR-Cas system are believed to be overcome by a synergistic combination of the nanoparticles system and CRISPR-Cas using nanoparticles as vehicles. In this review, we have discussed the diagnostic application of CRISPR-Cas technologies along with their potential usage in applications like phage resistance, phage vaccination, strain typing, genome editing, and antimicrobial. we have also elucidated the antimicrobial and detection role of nanoparticles against foodborne MDR pathogens. Moreover, the novel combinatorial approach of CRISPR-Cas and nanoparticles for their synergistic effects in pathogen clearance and drug delivery vehicles has also been discussed. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2590-0064 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2590006422000898; https://doaj.org/toc/2590-0064 |
| DOI: | 10.1016/j.mtbio.2022.100291 |
| URL الوصول: | https://doaj.org/article/23a5e16d413848d2826cc329d4ab73b0 |
| رقم الأكسشن: | edsdoj.23a5e16d413848d2826cc329d4ab73b0 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 25900064 |
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| DOI: | 10.1016/j.mtbio.2022.100291 |