دورية أكاديمية
Effects of Luteinizing Hormone Supplementation on Ovarian Response and Assisted Reproductive Technology Outcomes in Antagonist In vitro Fertilization/Intracytoplasmic Sperm Injection Cycles: A Meta-analysis
| العنوان: | Effects of Luteinizing Hormone Supplementation on Ovarian Response and Assisted Reproductive Technology Outcomes in Antagonist In vitro Fertilization/Intracytoplasmic Sperm Injection Cycles: A Meta-analysis |
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| المؤلفون: | Lei Chen, Cai-Rong Chen, Xue-Jian Kong, Cheng-Ran Qiu |
| المصدر: | Reproductive and Developmental Medicine, Vol 3, Iss 2, Pp 89-96 (2019) |
| بيانات النشر: | Wolters Kluwer Health/LWW, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Immunologic diseases. Allergy LCC:Diseases of the endocrine glands. Clinical endocrinology |
| مصطلحات موضوعية: | Assisted Reproductive Technology, Gonadotropin-Releasing Hormone Antagonist Protocol, Luteinizing Hormone Supplementation, Meta-Analysis, Immunologic diseases. Allergy, RC581-607, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| الوصف: | Objective: The study objective was to investigate the effects of luteinizing hormone (LH) supplementation on ovarian response and assisted reproductive technology (ART) outcomes in in vitro fertilization/intracytoplasmic sperm injection cycles with a gonadotropin (Gn)-releasing hormone antagonist protocol. Methods: This is a meta-analysis, and nine published randomized controlled trials (1,685 patients) were included. Continuous data were extracted in the form of mean ± standard deviation and population size, whereas dichotomous data were extracted in the form of odds ratio. Results: The total amount of follicle-stimulating hormone (FSH) used, the duration of stimulation (DOS), the number of eggs in MII stage, the total number of formed embryos, the clinical pregnancy rate, and live birth rates were similar between groups, but the estrogen level on the day of human chorionic Gn (hCG) administration was slightly higher in the LH supplementation group. On subgroup analysis, it was reported that the addition of LH could significantly increase estrogen levels on the day of hCG administration in patients older than 35 years, and LH supplementation starting on the day of FSH administration may slightly extend the DOS. Moreover, regardless of the timing of LH supplementation, an increase in estrogen levels was found on the day of hCG administration. Conclusions: LH supplementation of an antagonist protocol increases estrogen levels on the day of hCG administration, but does not increase the number of mature oocytes retrieved, and also fails to improve ART outcomes. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2096-2924 2589-8728 |
| Relation: | http://www.repdevmed.org/article.asp?issn=2096-2924;year=2019;volume=3;issue=2;spage=89;epage=96;aulast=Chen; https://doaj.org/toc/2096-2924; https://doaj.org/toc/2589-8728 |
| DOI: | 10.4103/2096-2924.262386 |
| URL الوصول: | https://doaj.org/article/23e56ab36533448db60903e64ca5c217 |
| رقم الأكسشن: | edsdoj.23e56ab36533448db60903e64ca5c217 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20962924 25898728 |
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| DOI: | 10.4103/2096-2924.262386 |