دورية أكاديمية
A novel digital tool for detection and monitoring of amyotrophic lateral sclerosis motor impairment and progression via keystroke dynamics
| العنوان: | A novel digital tool for detection and monitoring of amyotrophic lateral sclerosis motor impairment and progression via keystroke dynamics |
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| المؤلفون: | Alejandro Acien, Narghes Calcagno, Katherine M. Burke, Ijah Mondesire-Crump, Ashley A. Holmes, Sri Mruthik, Ben Goldy, Janina E. Syrotenko, Zoe Scheier, Amrita Iyer, Alison Clark, Mackenzie Keegan, Yoshiteru Ushirogawa, Atsushi Kato, Taku Yasuda, Amir Lahav, Satoshi Iwasaki, Mark Pascarella, Stephen A. Johnson, Teresa Arroyo-Gallego, James D. Berry |
| المصدر: | Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024) |
| بيانات النشر: | Nature Portfolio, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Amyotrophic lateral sclerosis, Digital biomarkers, Keystroke dynamics, Fine motor, ALSFRS-R, Machine learning, Medicine, Science |
| الوصف: | Abstract Amyotrophic lateral sclerosis (ALS) is a debilitating neurodegenerative condition leading to progressive muscle weakness, atrophy, and ultimately death. Traditional ALS clinical evaluations often depend on subjective metrics, making accurate disease detection and monitoring disease trajectory challenging. To address these limitations, we developed the nQiALS toolkit, a machine learning-powered system that leverages smartphone typing dynamics to detect and track motor impairment in people with ALS. The study included 63 ALS patients and 30 age- and sex-matched healthy controls. We introduce the three core components of this toolkit: the nQiALS-Detection, which differentiated ALS from healthy typing patterns with an AUC of 0.89; the nQiALS-Progression, which separated slow and fast progression at specific thresholds with AUCs ranging between 0.65 and 0.8; and the nQiALS-Fine Motor, which identified subtle progression in fine motor dysfunction, suggesting earlier prediction than the state-of-the-art assessment. Together, these tools represent an innovative approach to ALS assessment, offering a complementary, objective metric to traditional clinical methods and which may reshape our understanding and monitoring of ALS progression. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-024-67940-8 |
| URL الوصول: | https://doaj.org/article/2498bc03479647a985a2b9a0dfe827ac |
| رقم الأكسشن: | edsdoj.2498bc03479647a985a2b9a0dfe827ac |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-024-67940-8 |