دورية أكاديمية
Assessing whether serum ceruloplasmin promotes non-alcoholic steatohepatitis via regulating iron metabolism
| العنوان: | Assessing whether serum ceruloplasmin promotes non-alcoholic steatohepatitis via regulating iron metabolism |
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| المؤلفون: | Xia Ziqiang, Hu Mei, Zheng Liang, Zheng Endian, Deng Min, Wu Jinming, Sheng Xiong |
| المصدر: | Journal of Medical Biochemistry, Vol 42, Iss 1, Pp 113-121 (2023) |
| بيانات النشر: | Society of Medical Biochemists of Serbia, Belgrade, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Biochemistry |
| مصطلحات موضوعية: | ceruloplasmin, ferritin, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, Biochemistry, QD415-436 |
| الوصف: | Background: Non-alcoholic steatohepatitis (NASH) is a progressive form of non-alcoholic fatty liver disease (NAFLD). The diagnostic gold standard for detecting NASH still relies upon an invasive pathological biopsy. There is, therefore, a need to identify non-invasive diagnostic markers. Oxidative stress mediates fatty liver progression to NASH. Imbalanced iron metabolism produces many reactive oxygen species (ROS). Ceruloplasmin is associated with oxidase and iron metabolism-related activities. The current study aimed to determine whether there was a correlation between ceruloplasmin levels and NASH and whether such a relationship may be associated with altered iron metabolism in NASH patients. Methods: A total of 135 NAFLD patients were enrolled in this study. A pathological biopsy confirmed that 60 of those patients had NAFLD activity scores (NAS) 5, while the remaining 75 had NAS |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1452-8258 1452-8266 |
| Relation: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2023/1452-82582301113X.pdf; https://doaj.org/toc/1452-8258; https://doaj.org/toc/1452-8266 |
| DOI: | 10.5937/jomb0-37597 |
| URL الوصول: | https://doaj.org/article/24c2c1a498ce4d1a995de56009f84c1e |
| رقم الأكسشن: | edsdoj.24c2c1a498ce4d1a995de56009f84c1e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14528258 14528266 |
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| DOI: | 10.5937/jomb0-37597 |