دورية أكاديمية
Clinical Features of Non-Alcoholic Fatty Liver Disease in the Non-Lean Population
| العنوان: | Clinical Features of Non-Alcoholic Fatty Liver Disease in the Non-Lean Population |
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| المؤلفون: | Min-ran Li, Jin-Zhong Li, Jie-ying Li, Cun-chuan Wang, Rui-kun Yuan, Li-hong Ye, Yun-yan Liu, Xu-jing Liang, Hai-cong Zhang, Zhi-quan Liu, Dong-yu Zeng, Xue-dong Zhang, De-hua Wang, Jun-qing Li, Tao-yuan Li, Liu Yang, Yang Cao, Yun Pan, Xun-ge Lin, Calvin Q Pan, Er-hei Dai, Zhi-yong Dong |
| المصدر: | Obesity Facts, Pp 1-1 (2023) |
| بيانات النشر: | Karger Publishers, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Nutrition. Foods and food supply LCC:Nutritional diseases. Deficiency diseases |
| مصطلحات موضوعية: | non-alcoholic fatty liver disease, overweight, obese, fibrosis, Nutrition. Foods and food supply, TX341-641, Nutritional diseases. Deficiency diseases, RC620-627 |
| الوصف: | Introduction: The prevalence of non-alcoholic fatty liver disease (NAFLD) in non-lean patients is significantly increased, and obesity significantly increases the risk of cirrhosis and HCC in NAFLD patients. However, whether there is a difference in clinical manifestations of NAFLD between overweight and obesity remains unclear. The objective of this study was to assess the clinical and histological features of NAFLD among a non-lean population. Methods: Current study enrolled consecutive non-lean (body mass index [BMI] >23 kg/m2) patients with NAFLD and available liver biopsy results. Patients were stratified by BMI into two groups for the comparison of their clinical and histological variables, which included the overweight (BMI 23 ∼1) were also analyzed through the logistic regression model. Results: Among 184 non-lean patients with metabolic-associated fatty liver disease enrolled, 65 and 119 were overweight and obese, respectively. Patients in the obesity group had a significantly lower level of gamma-glutamyl transpeptidase, higher levels of platelet, glucose, prothrombin time, and more common of moderate to severe inflammatory activity when compared to those in the overweight group. However, a significant low frequency of moderate to severe fibrosis was found in the obesity group versus the overweight group (19.33% vs. 40.00%, p = 0.002). Binary logistics regression analysis of fibrosis found that aspartate transaminase (AST), BMI, alanine transaminase (ALT), and cholesterol (CHOL) were independent predictors for moderate to severe fibrosis in non-lean patients with NAFLD. Compared with the traditional fibrosis-4 (AUC = 0.77) and aminotransferase to platelet ratio index (AUC = 0.79) indexes, the combined index based on AST, BMI, ALT, and CHOL was more accurate in predicting moderate to severe fibrosis in non-lean patients with NAFLD (AUC = 0.87). Conclusions: Clinical and histological features differed between obesity and overweight patients with NAFLD. When compared to the traditional serum markers, the combination index including AST, BMI, ALT, and CHOL provided a better model to predict moderate to severe fibrosis in non-lean patients with NAFLD. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1662-4025 1662-4033 |
| Relation: | https://beta.karger.com/Article/FullText/530845; https://doaj.org/toc/1662-4025; https://doaj.org/toc/1662-4033 |
| DOI: | 10.1159/000530845 |
| URL الوصول: | https://doaj.org/article/24e6aa5e1ff143d8a0e39a158b81d52a |
| رقم الأكسشن: | edsdoj.24e6aa5e1ff143d8a0e39a158b81d52a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16624025 16624033 |
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| DOI: | 10.1159/000530845 |