دورية أكاديمية
The Effect of Superparamagnetic Fe3O4 Nanoparticles Combined with Quercetin on Breast Cancer Cell Line (MCF-7)
| العنوان: | The Effect of Superparamagnetic Fe3O4 Nanoparticles Combined with Quercetin on Breast Cancer Cell Line (MCF-7) |
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| المؤلفون: | Fateme Sadeghi Nodoushan, Fatemeh Hakimian, Bibi Fatemeh Haghiralsadat, Sana Taghiyar |
| المصدر: | Journal of Nutrition and Food Security, Vol 8, Iss 4, Pp 565-576 (2023) |
| بيانات النشر: | Shahid Sadoughi University of Medical Sciences and Health Services, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Agriculture LCC:Nutrition. Foods and food supply |
| مصطلحات موضوعية: | nanoparticles, quercetin, fe3o4, breast cancer, Agriculture, Nutrition. Foods and food supply, TX341-641 |
| الوصف: | Background: Magnetic nanoparticles attract increasing interest due to their use in cancer therapy and as drug carriers for several other diseases. The present study investigates the physiochemical properties of quercetin-conjugated superparamagnetic Fe3O4 nanoparticles and their effects on breast cancer cell line MCF-7. Methods: A simple precipitation method was used to prepare the Poly Ethylene Imine (PEI)-coated Fe3O4 nanoparticles; they were then conjugated with flavonoid-compound quercetin on the surface via carboxylic/amine group using nanoprecipitation method. Then, the physical and chemical parameters were calculated using Zeta-sizer, scanning electron microscopy (SEM), and extract release patterns at 37 and 42 0C. Finally, the toxicity level of this quercetin- conjugated nanosystem on the MCF-7 cells was investigated by MTT assay. Results: The results showed that the prepared nanosystem attained about 74% of quercetin inclusion, 91.2 nm size, 65.1 mV zeta potential, spherical morphology and a controlled release. Compared to Fe3O4 nanoparticles and pure quercetin, MTT and microscopy analysis revealed that quercetin-conjugated Fe3O4 nanoparticles induced considerable cytotoxicity, and morphology changes against MCF7 cells. Conclusion: Quercetin-conjugated Fe3O4 nanoparticles have appropriate physiochemical properties; they can be a suitable carrier for drug delivery and a promising therapy for candidates. Corresponding Author:Bibi Fatemeh Haghiralsadat View Orcid in Profile You can search for this author in PubMed Google Scholar Profile |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2476-7417 2476-7425 |
| Relation: | http://jnfs.ssu.ac.ir/article-1-893-en.pdf; https://doaj.org/toc/2476-7417; https://doaj.org/toc/2476-7425 |
| URL الوصول: | https://doaj.org/article/254bb8ca13a54a44a5e1936042eaaa7a |
| رقم الأكسشن: | edsdoj.254bb8ca13a54a44a5e1936042eaaa7a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24767417 24767425 |
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