CRISPR-LbCpf1 prevents choroidal neovascularization in a mouse model of age-related macular degeneration

التفاصيل البيبلوغرافية
العنوان:	CRISPR-LbCpf1 prevents choroidal neovascularization in a mouse model of age-related macular degeneration
المؤلفون:	Taeyoung Koo, Sung Wook Park, Dong Hyun Jo, Daesik Kim, Jin Hyoung Kim, Hee-Yeon Cho, Jeungeun Kim, Jeong Hun Kim, Jin-Soo Kim
المصدر:	Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
بيانات النشر:	Nature Portfolio, 2018.
سنة النشر:	2018
المجموعة:	LCC:Science
مصطلحات موضوعية:	Science
الوصف:	The CRISPR endonuclease LbCpf1 is reported to have greater efficiency and specificity than Cas9. Here, the authors use LbCpf1 to target the angiogenesis-related genes VEGF and HIF1a, and show that delivery of the nuclease using AAV9 is effective in mouse models of macular degeneration.
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	2041-1723
Relation:	https://doaj.org/toc/2041-1723
DOI:	10.1038/s41467-018-04175-y
URL الوصول:	https://doaj.org/article/25757b2b16cb4f498da30b72b2a47f63
رقم الأكسشن:	edsdoj.25757b2b16cb4f498da30b72b2a47f63
قاعدة البيانات:	Directory of Open Access Journals

الوصف
تدمد:	20411723
DOI:	10.1038/s41467-018-04175-y