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Synthesis, characterization and biological activity of Pt(II) complexes with steroidal thiosemicarbazones

التفاصيل البيبلوغرافية
العنوان: Synthesis, characterization and biological activity of Pt(II) complexes with steroidal thiosemicarbazones
المؤلفون: Čobeljić Božidar R., Živković Marijana B., Matić Ivana Z., Novaković Irena T., Sladić Dušan M., Anđelković Katarina K., Krstić Natalija M.
المصدر: Journal of the Serbian Chemical Society, Vol 86, Iss 5, Pp 459-468 (2021)
بيانات النشر: Serbian Chemical Society, 2021.
سنة النشر: 2021
المجموعة: LCC:Chemistry
مصطلحات موضوعية: 3-oxo-α, β-unsaturated steroids, hydrazones, square-planar complexes, cytotoxicity, antimicrobial activity, Chemistry, QD1-999
الوصف: In this work, Pt(II) complexes of previously synthesized steroidal thiosemicarbazones were synthesized and characterized. The ligands and their metal complexes were studied by analytical and spectroscopic data (elemental analysis, IR, 1D-NMR and 2D-NMR, HSQC, HMBC, NOESY, COSY), the analysis of which enabled complete 1H and 13C assignments of each compound including E and Z isomers. All the synthesized ligands and complexes were screened for their cytotoxic and antimicrobial activity. The results demonstrate that the new steroidal thiosemicarbazone complexes were significantly less cytotoxic than the corresponding steroidal thiosemicarbazones. In addition, complexes showed lower antimicrobial activity than the standard drugs, similar to the activity of the starting thiosemicarbazones.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 0352-5139
1820-7421
Relation: https://doaj.org/toc/0352-5139; https://doaj.org/toc/1820-7421
DOI: 10.2298/JSC201211083C
URL الوصول: https://doaj.org/article/258f5943d69b4abf999a9a276b0d069c
رقم الأكسشن: edsdoj.258f5943d69b4abf999a9a276b0d069c
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:03525139
18207421
DOI:10.2298/JSC201211083C