دورية أكاديمية
Genome-wide data from the Bubi of Bioko Island clarifies the Atlantic fringe of the Bantu dispersal
| العنوان: | Genome-wide data from the Bubi of Bioko Island clarifies the Atlantic fringe of the Bantu dispersal |
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| المؤلفون: | Pere Gelabert, Manuel Ferrando-Bernal, Toni de-Dios, Benedetta Mattorre, Elena Campoy, Amaya Gorostiza, Etienne Patin, Antonio González-Martín, Carles Lalueza-Fox |
| المصدر: | BMC Genomics, Vol 20, Iss 1, Pp 1-13 (2019) |
| بيانات النشر: | BMC, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Biotechnology LCC:Genetics |
| مصطلحات موضوعية: | Bubi, Bioko Island, Bantu-speaking groups, Population genetics, Isolation, Biotechnology, TP248.13-248.65, Genetics, QH426-470 |
| الوصف: | Abstract Background Bioko is one of the few islands that exist around Africa, the most genetically diverse continent on the planet. The native Bantu-speaking inhabitants of Bioko, the Bubi, are believed to have colonized the island about 2000 years ago. Here, we sequenced the genome of thirteen Bubi individuals at high coverage and analysed their sequences in comparison to mainland populations from the Gulf of Guinea. Results We found that, genetically, the closest mainland population to the Bubi are Bantu-speaking groups from Angola instead the geographically closer groups from Cameroon. The Bubi possess a lower proportion of rainforest hunter-gatherer (RHG) ancestry than most other Bantu-speaking groups. However, their RHG component most likely came from the same source and could have reached them by gene flow from the mainland after island settlement. By studying identity by descent (IBD) genomic blocks and runs of homozygosity (ROHs), we found evidence for a significant level of genetic isolation among the Bubi, isolation that can be attributed to the island effect. Additionally, as this population is known to have one of the highest malaria incidence rates in the world we analysed their genome for malaria-resistant alleles. However, we were unable to detect any specific selective sweeps related to this disease. Conclusions By describing their dispersal to the Atlantic islands, the genomic characterization of the Bubi contributes to the understanding of the margins of the massive Bantu migration that shaped all Sub-Saharan African populations. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1471-2164 |
| Relation: | http://link.springer.com/article/10.1186/s12864-019-5529-0; https://doaj.org/toc/1471-2164 |
| DOI: | 10.1186/s12864-019-5529-0 |
| URL الوصول: | https://doaj.org/article/2590e85616814285af60e30cc4887f73 |
| رقم الأكسشن: | edsdoj.2590e85616814285af60e30cc4887f73 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 14712164 |
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| DOI: | 10.1186/s12864-019-5529-0 |