دورية أكاديمية
THE BIOCHEMICAL RESPONSES OF BIVALVE MOLLUSCS TO NEUROLEPTIC CHLORPROMAZINE ARE COMPARABLE WITH THE RESPONSES OF HIGHER VERTEBRATES
| العنوان: | THE BIOCHEMICAL RESPONSES OF BIVALVE MOLLUSCS TO NEUROLEPTIC CHLORPROMAZINE ARE COMPARABLE WITH THE RESPONSES OF HIGHER VERTEBRATES |
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| المؤلفون: | K. Yunko, F. IMPELLITTERI, V. MARTYNIUK, C.R. MULTISANTI, M. ZABOLOTNA, V. KHOMA, T. MATSKIV |
| المصدر: | Biotechnologia Acta, Vol 17, Iss 2, Pp 90-92 (2024) |
| بيانات النشر: | National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Biotechnology |
| مصطلحات موضوعية: | pharmaceuticals, bivalve mollusc, ecotoxicity, oxidative stress, biotransformation, apoptosis., Biotechnology, TP248.13-248.65 |
| الوصف: | Pharmaceuticals such as chlorpromazine (Cpz) are emerging aquatic pollutants with potential effects on non-target organisms. However, its effects on aquatic organisms remain limited and inconclusive. The aim of this study was to compare the responses to Cpz in marine and freshwater bivalve molluscs. Methods. Mytilus galloprovincialis and Unio tumidus were exposed to pM and nM concentrations of Cpz for 14 days and analysed 16 parameters, including cytotoxicity, oxidative/reductive stress responses, metallothionein concentration and biotransformation enzymes in the digestive gland. Results. In both species, Cpz increased EROD activity, possibly leading to the formation of reactive metabolites. Marine mussels exposed to Cpz I and II showed increased GST activity, suggesting detoxification, whereas freshwater mussels showed decreased GST activity, suggesting higher Cpz toxicity. Activation of the GTPase dynamin in U. tumidus exposed to Cpz I confirmed the effect of Cpz on endocytosis. Oxidative stress responses were observed in both species, with changes in oxidative/reductive stress responses, suggesting toxic effects of Cpz. GSH and metallothionein concentrations increased in all exposures, while the NADH/NAD+ ratio increased significantly in U. tumidus. Loss of lysosomal membrane stability was observed in all exposed groups, with CtD efflux detected only in mussels. Differences in caspase-3 activity were also observed between species. Conclusion. Cpz showed adverse effects on vertebrates at μM concentrations, while mussels were affected at pM to nM concentrations, indicating concentration-dependent interspecies effects. Stress responses were similar between species, suggesting that marine molluscs are a potential model for assessing the adverse effects of Cpz on higher vertebrates. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Ukrainian |
| تدمد: | 2410-7751 2410-776X |
| Relation: | https://biotechnology.kiev.ua/images/BTA/2024/2_2024/Yunko_2_2024.pdf; https://doaj.org/toc/2410-7751; https://doaj.org/toc/2410-776X |
| DOI: | 10.15407/biotech17.02.090 |
| URL الوصول: | https://doaj.org/article/25a4c1615ef3476e85c9aac26ef180f8 |
| رقم الأكسشن: | edsdoj.25a4c1615ef3476e85c9aac26ef180f8 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24107751 2410776X |
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| DOI: | 10.15407/biotech17.02.090 |