دورية أكاديمية
The Presence of Circulating Nucleated Red Blood Cells Is Associated With Disease Severity in Patients of Hemorrhagic Fever With Renal Syndrome
| العنوان: | The Presence of Circulating Nucleated Red Blood Cells Is Associated With Disease Severity in Patients of Hemorrhagic Fever With Renal Syndrome |
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| المؤلفون: | Jingang Zhang, Kang Tang, Yun Zhang, Ying Ma, Chunmei Zhang, Haifeng Hu, Xiaozhou Jia, Ran Zhuang, Boquan Jin, Meng Wang, Xiyue Zhang, Dalu Liu, Yusi Zhang |
| المصدر: | Frontiers in Medicine, Vol 8 (2021) |
| بيانات النشر: | Frontiers Media S.A., 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine (General) |
| مصطلحات موضوعية: | HTNV, HFRS, NRBC, vitamin B12 (B12), folic acid (B9), Medicine (General), R5-920 |
| الوصف: | Hemorrhagic fever with renal syndrome (HFRS) is a regional infectious disease of epidemic potential caused by the Hantaan virus (HTNV). Red blood cells (RBCs) are the major components of peripheral blood. However, pathological changes in RBCs and the underlying mechanisms during HTNV infection remain largely unclear. Therefore, this study sought to explore changes in RBCs in the peripheral blood of HFRS patients. We isolated PBMCs from HFRS patients and performed single-cell RNA sequencing. The results showed that clusters of RBCs in the peripheral blood of HFRS could be classified as nucleated red blood cells (NRBC) based on their cellular components, gene expression profiles and cell surface markers. In addition, it was shown that the higher the count of NRBC in peripheral blood, the more severe the disease status was. Moreover, hematological indices related to RBCs were analyzed and the results showed that impairment in the folate pathway might be the possible reason behind the presence of NRBCs. This study, for the first time showed that the presence of NRBCs in the peripheral blood of HFRS patients was associated with disease severity. This was also the first study to show that infection with the HTNV virus hindered the maturation of RBCs. Therefore, this work provides further insights on the role of and pathological changes in RBCs during HTNV infection. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2296-858X 88080234 |
| Relation: | https://www.frontiersin.org/articles/10.3389/fmed.2021.665410/full; https://doaj.org/toc/2296-858X |
| DOI: | 10.3389/fmed.2021.665410 |
| URL الوصول: | https://doaj.org/article/25baa88080234be5a1239cc4fa1521e1 |
| رقم الأكسشن: | edsdoj.25baa88080234be5a1239cc4fa1521e1 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2296858X 88080234 |
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| DOI: | 10.3389/fmed.2021.665410 |