دورية أكاديمية
Human Homeobox TGIFLX Regulates CDX1, CDX2, and OCT1 Genes Expression in Colorectal Cancer Cell Lines
| العنوان: | Human Homeobox TGIFLX Regulates CDX1, CDX2, and OCT1 Genes Expression in Colorectal Cancer Cell Lines |
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| المؤلفون: | Soroosh Shahryarhesami, Mansour Heidari, Masoud Heidari, Nahid Sadighi |
| المصدر: | Middle East Journal of Cancer, Vol 13, Iss 2, Pp 216-225 (2022) |
| بيانات النشر: | Shiraz University of Medical Sciences, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | colorectal neoplasms, homeobox genes, rna, small interfering, mutation, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Background: Homeodomain transcriptional regulatory proteins, which are encoded by Homeobox (HOX) genes, play critical roles in both normal development and carcinogenesis. Previous studies have shown that the expression of HOX genes is deregulated in numerous tumors and this expression is specific to each cancer based on the arising embryonic origin tissue and the site of tumor. Method: In this in vitro study, the expression levels of HOXA10, CDX1, CDX2, TGIFLX, TGIFLY, and OCT1 genes were compared across 10 different human colorectal cancer cell lines with different differentiation stages. Subsequently, the effect of TGIFLX siRNA-mediated knockdown on the expression levels of CDX1, CDX2, and OCT1 genes was analyzed in SW948 cell line. Results: The obtained results revealed that these homeobox genes were differentially expressed in different colorectal cancer cell lines. Furthermore, the siRNA-mediated knockdown of TGIFLX led to higher levels of CDX1, CDX2, and OCT1 expression. Conclusion: Our data suggested that TGIFLX plays an important role in the upstream regulation of CDX1, CDX2, and OCT1 genes. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2008-6709 2008-6687 |
| Relation: | https://mejc.sums.ac.ir/article_47623_fe48601a9be70c4689680438374f947b.pdf; https://doaj.org/toc/2008-6709; https://doaj.org/toc/2008-6687 |
| DOI: | 10.30476/mejc.2021.86467.1345 |
| URL الوصول: | https://doaj.org/article/25d34d6731be42c08ac22ad4468a1703 |
| رقم الأكسشن: | edsdoj.25d34d6731be42c08ac22ad4468a1703 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20086709 20086687 |
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| DOI: | 10.30476/mejc.2021.86467.1345 |