دورية أكاديمية
Balancing in a black box: Potential immunomodulatory roles for TGF-β signaling during blood-stage malaria
| العنوان: | Balancing in a black box: Potential immunomodulatory roles for TGF-β signaling during blood-stage malaria |
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| المؤلفون: | Lisa L. Drewry, John T. Harty |
| المصدر: | Virulence, Vol 11, Iss 1, Pp 159-169 (2020) |
| بيانات النشر: | Taylor & Francis Group, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Infectious and parasitic diseases |
| مصطلحات موضوعية: | malaria, tgf-β, inflammation, Infectious and parasitic diseases, RC109-216 |
| الوصف: | Malarial disease caused by Plasmodium parasites challenges the mammalian immune system with a delicate balancing act. Robust inflammatory responses are required to control parasite replication within red blood cells, which if unchecked, can lead to severe anemia and fatality. However, the same inflammatory response that controls parasite replication is also associated with immunopathology and severe disease, as is exemplified by cerebral malaria. A robust literature has identified critical roles for innate, cellular, and humoral immune responses orchestrated by IFN-γ and TH1 type responses in controlling blood stage malarial disease. In contrast, TGF-β and IL-10 have been identified as important anti–inflammatory immunomodulators that help to limit inflammation and pathology during malaria. TGF-β is a pleiotropic cytokine, with the ability to exert a wide variety of context-dependent immunomodulatory roles. The specific mechanisms that allow TGF-β to protect against malarial pathology remain essentially unexplored and offer a promising avenue to dissect the most critical elements of immunomodulation in avoiding severe malaria. Here we discuss potential immunomodulatory roles for TGF-β during malaria in light of recent advances in our understanding of the role of Tregs during blood-stage malaria. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2150-5594 2150-5608 21505594 |
| Relation: | https://doaj.org/toc/2150-5594; https://doaj.org/toc/2150-5608 |
| DOI: | 10.1080/21505594.2020.1726569 |
| URL الوصول: | https://doaj.org/article/ed25f218519843fb8eeb1e97a0716ef7 |
| رقم الأكسشن: | edsdoj.25f218519843fb8eeb1e97a0716ef7 |
| قاعدة البيانات: | Directory of Open Access Journals |
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Full Text Finder | تدمد: | 21505594 21505608 |
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| DOI: | 10.1080/21505594.2020.1726569 |